Manish Goswami, U.K.Singh, Rajat Kumar
Kharvel subharti college of pharmacy (swami Vivekanandsubharti University) Subhartipuram,
N.H-58, Meerut By Pass Road,
Meerut, uttarpradesh- 250001, India.
The desire of improved palatability in orally administered products has prompted thedevelopment of numerous formulations with improved performance and acceptability. Mouth dissolving tablets (MDTs) have received ever-increasing demand during the last fewdecades, and the field has become a rapidly growing area in the pharmaceutical industry. Theunique property of mouth dissolving tablet is that they are rapidly disintegrating and/ordissolving and release the drug as soon as they come in contact with saliva, thus obviate therequirement of water during administration. this review also provides the detailed concept of some unique patents; technologiesdeveloped and marketed formulations of Mouth Dissolving Tablets(MDTs).The present investigation was undertaken with a view to develop mouth-dissolving tablets which offer a new range of product having desired characteristics and intended benefits. Mouth dissolving tablets are advantageous particularly for pediatric, geriatric and mentally ill patients who have difficulty in swallowing conventional tablets and capsules. The basic approach used in development of MDT is the use of super disintegrants like Crosslinked carboxymethyl cellulose (Croscarmellose), Sodium starch glycolate (Primogel, Explotab). Polyvinylpyrrolidone (Polyplasdone) etc. whichprovide instantaneous disintegration of tablet after putting on tongue, thereby releasing the drug in saliva.