Madhya Pradesh

Inviting applications for Pharmacist in M.P. State AIDS Control Society - 5 posts

The first case of HIV/AIDS was detected in MP in 1988, and since then the number of Aids cases is rising. In view of the seriousness of the problem, MP Government constituted AIDS control cell in 1992 under medical education department. Subsequently MP state AIDS control society was constituted on 14/7/1998. MPSACS takes policy decisions for effective implementation of AIDS control programme in MP. It is an autonomous institution, funded by National AIDS control organization (NACO).

Post: Pharmacist

PRODRUGS: AN OVERVIEW

About Authors:
Deepti Soni*, Rathore KS1, Nema RK2
*College of Pharmaceutical Sciences, Behrampur, Orissa
1BN Institute of Pharmaceutical Sciences, Udaipur, Raj.
2Rishiraj College of Pharmacy, Indore-MP
*deepti_jazz@yahoo.com

Introduction
A prodrug is a pharmacological substance (drug) that is administered in an inactive (or significantly less active) form. Once administered, the prodrug is metabolised in vivo into an active metabolite (Wadhwa LK, 1994). Almost all drugs possess some undesirable physiochemical and biological properties. Their therapeutic efficacy can be improved by minimizing or eliminating the undesirable properties while retaining the desirable ones.  This can be achieved through biological, physical or chemical means (Loe A, 1971, Balant LP, E Doelker, et al., 1990, Jha V, 1995).

  • The biological approach is to alter the route of administration, which may or may not be acceptable to the patient.
  • The physical approach is to modify the design of the dosage form such as controlled delivery of drugs.
  • The chemical approach is the best approach in enhancing drug selectivity and minimizing the toxicity.

Walk in interview for the post of QC, Production (api) & Pilot Plant in IPCA Laboratories | 35 Posts

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ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF ZINC PYRITHIONE IN KETOCONAZOLE SHAMPOO BY RP-HPLC METHOD

ABOUT AUTHORS:
Sahoo.U1*, Sethy.S.P1, Biswal.S1, Patro.S.K1, Banerjee.M1, Sundeep Kumar.H.K.S1, Patel.D2
*1Department of Pharmaceutical Chemistry
Institute of Pharmacy and Technology, Salipur, Cuttack, Odisha-754202
2ZYG Pharma, Pvt, Ltd, Pithampur, Madhya Pradesh
sarada9439504350@gmail.com

ABSTRACT-
A mobile phase consisting of Acetonitrile and water in the ratio of 60:40 gave a well resolved and sharp peak for Zinc-Pyrithione with a retention time of 11.61 mins. The flow rate was 1 ml/min and effluent was monitored at 322 nm. Zobrax C18 column, run time of 30 min and ambient temperatures were found to be optimum for the analysis. System suitability was performed by injecting five replicate injections of working standard solution. The System suitability results obey all the parameters and found within the acceptable range. The precision study was found to be less than 1 (% RSD). So, it indicates the method is precise. The recovery study was found to be 98 to 102 % and % RSD was found to be less than % 1. So, the method is more accurate, precise, and sensitive.

PHYTO-PHARMACOLOGICAL AND AGRONOMICAL PROFILE OF IXORA PARVIFLORA

ABOUT AUTHORS:
Das Sattwik1, Sharma Shikha1, Lariya Shailendra2
1Malhotra College, Department of pharmacology, Badwai, Bhopal, M.P., India
2Radha raman Institute of Pharmaceutical Science, Bhopal, M. P., India
*dsattwik@gmail.com

ABSTRACT
Ixora parviflora
an Indian plant, has long been medicinally used in traditional systems of medicine. The plant has been found to possess varied number of pharmacological activities. This article gives an account of updated information on its phytochemical and pharmacological properties. The review reveals that wide numbers of phytochemical constituents have been isolated from the plant which possesses activities like anaemia, whooping cough, antiviral, hypotensive and spasmolytic. These reports are very hopeful and indicate that the plant should be studied more widely for its therapeutic effects.

ETODOLAC: A PHARMACOECONOMIC AND CLINICALLY EFFECTIVE NSAID FOR ARTHRITIS

ABOUT AUTHORS:
Bhale Shweta*, Saxena Vaishali, Bhandari Govind, Mahajan S.C.
Mahakal Institute of Pharmaceutical studies,
Ujjain (m.p)
*bhaleshweta11@gmail.com

ABSTRACT:
Connective tissue disease include the following state: rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus, polyarteritis nodosa, gout, rheumatic fever and osteoarthritis, with the most  common forms of which are rheumatoid arthritis, osteoporosis and gout. Rheumatoid arthritis is a chronic, nonsuppurative inflammatory disease  of unknown cause affecting primarily peripheral synovial joint. the onset  is usually insidious, with  immunological reaction playing a major role. Common  medications for arthritis include nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs decrease pain, inflammation, and fever by blocking cyclo-oxygenase (COX) enzymes. Understanding of the pharmacology of NSAIDs continues to evolve, but it is now thought that most NSAIDs block three different COX isoenzymes, known as COX-1, COX-2, and COX-3. COX-1 protects the lining of the stomach from acid. COX-2 is found in joint and muscle, and mediates effects on pain and inflammation. By blocking COX-2, NSAIDs reduce pain compared to placebo in patients with arthritis, low back pain, minor injuries, and soft tissue rheumatism. selective NSAIDs or “COX-2 selective NSAIDs” as drugs in the “coxib” class (celecoxib, rofecoxib, valdecoxib, etoricoxib, lumiracoxib). “partially selective NSAIDs” as other drugs shown to have partial in vitro COX-2 selectivity (etodolac, nabumetone, meloxicam).

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