Sagar Institute of Pharmacy & Technology,
Gandhi nagar, Bhopal (M.P.)
Acalypha indica Linn. consists of dried herb of Acalypha indica Linn. belonging to familyEuphorbiaceae. Within the Euphorbiaceae family, Acalypha indica is one of the biggest and most diverse, with nearly 450 species. Two thirds of its species are found in America, 19 of them in Venezuala, they are mainly used as ornamental, but with the rising of traditional medicine, these species are given medical properties painkillers, laxatives, anti-inflammatory and many others.The GC-MS analysis of methanol and acetone (70 : 30) extract prepared from the whole plant of Acalypha indica linn. revealed the presence of different phytochemicals.
*Virendra Sharma, Pooja Sinoriya, Sunil Sharma
Lakshmi Narain Academy of Pharmacy, Gwalior
To evaluate the anti-inflammatory and analgesic activity of methanolic extract of whole plant of Sida acuta in experimental animal models. Methanolic extract of whole plant of Sida acuta (MESA) (100, 200 and 400 mg/kg p.o.) was studied for its anti-inflammatory activity using Carrageenan induced rat paw edema animal model and analgesic activity at the same dose level using acetic acid induced writhing test and Hot plate analgesia in mice. The methanolic extract of whole plant of Sida acuta (MESA) (100, 200 and 400 mg/kg p.o.). The PI with indomethacin and Sida acuta in carrageenan induced paw edema at the dose level 400 mg/kg were 60% and 52.5% at the end of 5 hr. In the acetic acid induced writhing test, the extract at the dose level 400 mg/kg showed 83.78% inhibition of writhing. In radiant heat tail- flick method the extract at the dose 400 mg/kg showed reaction time 4.902 ± 0.545 (p<0.001). The methanolic extract possesses anti-inflammatory and analgesic activity.
Vaibhav Patel*, Punit Bhatnagar, Gopal Rai, Alok Pal Jain
Guru Ramdas Khalsa Institute of Science & Technology (Pharmacy),
Gene therapy by small interfering RNAs (siRNAs) hasbeen emerging as innovative nucleic acid medicines with increasing knowledge on the molecular mechanisms of endogenous RNA interference. Gene silencingis a promising tool for the treatment of numerous human diseases that cannot be cured by rational therapies. The primary success of siRNA applications depends on suitable vectors to deliver therapeutic genes.
Vivek Chourasia*, Hemant Nagar, H.S. Chandel, Anindya Goswami
Truba Institute of Pharmacy,
Karond Gandhinagar Bypass
Ficus religiosawas investigated for its possible protective effect against paracetamol and CCl4-induced hepatic damage. IV administration of a sub-lethal dose of paracetamol (500 mg/kg) produced liver damage in rats as manifested by the rise in serum level of transaminases (AST and ALT). Ttreatment of rats with Ficus religiosa (200 mg/kg) prevented the paracetamol-induced rise in serum enzymes. The hepatotoxic dose of CCl4 (1.5 ml/kg; orally) also raised the serum AST and ALT levels. The same dose of Ficus religiosa (200 mg/kg) was able to prevent the CCl4-induced rise in serum enzymes. These results indicate that Ficus religiosa possesses hepatoprotective activity.
Singh Asheesh1*, Bajpai Dinesh1, Singour P.K.2
1Centre for Research & Development, Ipca Laboratories Ltd; Sejavta; Ratlam (MP) - 457002
2Faculty of pharmacy VNS Institute, Neelbud Bhopal (MP) - 462042
Stevia rebaudiana is a well known medicinal herb contains antibacterial, antifungal, anti-inflammatory, anti-viral, anti-yeast, cardiotonic diuretic and hypoglycaemic properties. This herb has been used in Ayurveda in India since centuries. Stevia is a perennial herb belonging to the family Asteraceae, is one of the most valuable tropical medicinal plant. All over world there is increasing tendency towards consuming natural products and thus living a natural life and. At the same time our life styles have changed so much over the last 4-5 decades that sweeteners (either high calorie natural or proceeded sugars or high potency and low calorie sweeteners such as Aspartame) have become integral part of our natural daily diet. Stevia is a new crop in that is gaining very high popularity amongst all type of sweetener users as most ideal substitute for sugar. Sugar is basically a chemical that has grown in market over last many years. But in this age of changing life styles and people becoming more conscious of their health, the worldwide sugar consumption is going down and is getting replaced by low calorie sweeteners. Many of these Sweeteners are complex chemicals or many times naturals as well.
Shri G.S. Institute of Technology & Science is a grant in aid autonomous institute of Madhya Pradesh offering UG and PG programmes in Engineering/ Technology/Pharmacy/Applied Sciences & Management. The Institute invites applications in prescribed proforma from eligible candidates for the post of Assistant Professor, Associate Professor and Professor. The reservation for SC/ST/OBC/Women/PH category shall be applicable as per M. P. Government Norms.
Vishal Sharma1*, Alankar Shrivastava2
1Department of Pharmaceutics,
2Senior Lecturer Department of Pharmaceutical Analysis
B.R.NAHATA COLLEGE OF PHARMACY
(A SIRO Recognized by DSIR, Ministry of science & Technology, GOI)
MANDSAUR (M.P.) 458001
Antibiotics are chemical substances, either produced naturally by microorganisms or manufactured synthetically, that are lethal to other microorganisms. Antibiotic resistance (AR) describes the ability of a microorganism to be unaffected by (or resistant to) the effects of a particular antibiotic. A problem arises when a animal or person becomes infected with a disease-causing bacterium that harbors antibiotic resistance to the drug that would be the most suitable treatment for that infection.
India is a vast country of immense diversity.and for that the effectiveness of the antimicrobial was not same to all ,and the administration of them will either really cure or may act in opposite manner and will leads to the development os the antimicrobial resistance which is only due to the unaware use of the antibiotics.we had conducted the survey on some prescriptions of registered medicinal practitioner and find that there was an irrational use of antibiotic in our on community and this might be very serious as our survey is on the smallest level and what it may cause globally.So the use of antibiotic should be controlled.
The Food Safety and Standards Authority of India (FSSAI) is an autonomous statutory Authority set up under the Food Safety and Standards Act, 2006 for laying down science based standards for articles of food and to regulate their manufacture, storage, distribution, sale and import to ensure availability of safe and wholesome food for human consumption.
SHARMA AKANSHA*, AGRAWAL SHIKHA
SWAMI VIVEKANAND COLLEGE OF PHARMACY
KHANDWA ROAD INDORE (M.P.)
The main aim for performing this project is to increase the bioavailabilty of lamotrigine as well as its onset of action to control the seizures that occur during the epileptic attack. To serve this purpose we will use mucilage of oscimum basilicum as a natural superdisintegrant & later comparing it with different novel synthetic superdisintegrant. By preparing a rapid disintegrating tablet of lamotrigine, rapid action of same can be achieved easily.
As we know that superdisintegrant plays the major role in rapid disintegration of tablet, thus it is very important to select a right or correct superdisintegrant in all respect which fulfill its purpose without effecting other parameters of tablet formulation and gives quicker and better result, when the number of formulation with different combinations of superdisintegrants (Natural & Synthetic) will be made then it would become very easy to evaluate and get the formulation with maximum desirable results.Lamotrigine being a poorly water soluble drug, needs modification to make them water soluble.