Andhra Pradesh

About Authors:
Sreedhar Reddy C
M.Pharm, Department of Pharmaceutics,
Vasavi Insitute of Pharmaceutical Sciences,
Vasavi Nagar, Peddapalli (V), Kadapa (dist),
A.P, India

Abstract:
In this study, transdermal patches containing Itraconazole were prepared using different ratios of polyvinylpyrrolidone (PVP) and Hydroxy propyl methyl cellulose (HPMC) by solvent evaporation technique using 10%w/w of dibutyl phthalate incorporated as plasticizer. The drug matrix film of PVP and HPMC was casted on a polyvinylalcohol backing membrane that was previously dried at 60⁰C for 6 hrs. All the prepared formulations were subjected to physical studies (moisture content, moisture uptake, Tensile strength, flatness and Drug content determination), in vitro release studies and in vitro skin permeation studies. The physiochemical compatibility of the drug and the polymers studied by IR spectroscopy have absence of any incompatibility. In vitro permeation studies were performed across  skin using a Franz diffusion cell. Variations in drug release profiles among the formulations studied were observed. Based on a physicochemical and in vitro skin permeation study, formulation F1 (PVP/HPMC, 5:1) and F5 (PVP/HPMC, 1:5) were chosen for further in vivo experiments. The anti inflammatory effect and a sustaining action of Itraconazole from the two transdermal patches selected were studied by inducing paw edema in rats with 1% w/v carrageenan solution. Hence, it can be reasonably concluded that Itraconazole can be formulated into the transdermal matrix type patches to sustain its release characteristics.

Dr. Reddy's Laboratories (NYSE: RDY) is an emerging global pharmaceutical company with proven research capabilities. The company is vertically integrated with a presence across the pharmaceutical value chain. It produces finished dosage forms, active pharmaceutical ingredients and biotechnology products and markets them globally, with focus on India, US, Europe and Russia.

Dr. Reddy's Laboratories (NYSE: RDY) is an emerging global pharmaceutical company with proven research capabilities. The company is vertically integrated with a presence across the pharmaceutical value chain. It produces finished dosage forms, active pharmaceutical ingredients and biotechnology products and markets them globally, with focus on India, US, Europe and Russia.

About Authors:
Habibur Rahman¹, M.C Eswaraiah^2
1Department of Pharmacology,
²Dept. of Pharmacognosy,
Anurag Pharmacy College,
Ananthagiri (V), Kodad (M),
Nalgonda (Dt.), A.P-508206, India

ABSTRACT
Brain neurotransmitters like Dopamine, serotonin, Adrenaline, Glutamate and enzymes like Acetyl cholinesterase (AchE), Mono amino-oxidase (MAO-A & MAO-B) levels and antioxidant enzymes like Superoxide dismutase, catalase, peroxidase etc play important roles in different complex neurological disorders like Alzheimer’s disease(AD), Parkinsonism, depression etc. But biochemical estimation of these parameters is very difficult to conduct in simple laboratory. This review is a collection of simple spectroscopic methods to determine the common brain neurotransmitters and antioxidant enzymes.

Dr. Reddy's Laboratories (NYSE: RDY) is an emerging global pharmaceutical company with proven research capabilities. The company is vertically integrated with a presence across the pharmaceutical value chain. It produces finished dosage forms, active pharmaceutical ingredients and biotechnology products and markets them globally, with focus on India, US, Europe and Russia.

ABOUT AUTHORS:
G. JYOTHI REDDY*¹, A. SRILAKSHMI¹, S.SINDHUJA², N.K. SREE¹, SK.AFSAR¹, B.PRIYANKA¹, R.E.AMRUTHA^1
1 Department of Pharmacology, P. Rami Reddy Memorial College of Pharmacy, Kadapa, Andhra Pradesh, India.
² Sri Padmavathi School Of Pharmacy, Tiruchanoor, Tirupathi, Andhra Pradesh, India

ABSTRACT
The ethanolic leaf extract of Allophylus serratus shown significant (p<0.05) antidiarrheal activity on gastrointestinal motility with  castor oil- induced diarrheal model in rats. The results obtained revealed that the leaf extract possess pharmacological activity against diarrhoea and may possibly explain the use of the plant in traditional medicine. The extract tested at 200 and 400 mg/kg like the standard drug, loperamide significantly inhibited the frequency of defecation droppings compared to untreated control rats. This result is in support of previous claims in respect of antidiarrhoeal herbs.

National Institute of Nutrition (NIN) was founded by Sir Robert McCarrison in the year 1918 as ‘Beri-Beri’ Enquiry Unit in a single room laboratory at the Pasteur Institute, Coonoor, Tamil Nadu. Within a short span of seven years, this unit blossomed into a "Deficiency Disease Enquiry" and later in 1928, emerged as full-fledged "Nutrition Research Laboratories" (NRL) with Dr.

The Central Council for Research in Ayurvedic Sciences (CCRAS) is an autonomous body under the Department of Ayurveda, Yoga & Naturopathy, Unani, Siddha & Homoeopathy (AYUSH), Ministry of Health & Family Welfare, Government of India. The Council is an apex body in India for formulation, development and promotion of research in Ayurvedic system of medicine. The Council carries out its activities and functions through its network of 31 Institutions located all over India.