Andhra Pradesh

National Institute of Nutrition (NIN) was founded by Sir Robert McCarrison in the year 1918 as ‘Beri-Beri’ Enquiry Unit in a single room laboratory at the Pasteur Institute, Coonoor, Tamil Nadu. Within a short span of seven years, this unit blossomed into a "Deficiency Disease Enquiry" and later in 1928, emerged as full-fledged "Nutrition Research Laboratories" (NRL) with Dr. McCarrison as its first Director.

About Authors:
S.R.Edwin Singh^*
Department of Pharmaceutics, Seshachala College of Pharmacy,
Tirupathi – Chennai High way,   Puttur-517 583, 
Chittoor (dist), A.P., India.

Abstract:
This article aims to review the recent developments in the buccal adhesive drug delivery systems to provide basic principles to the young scientists, which will be useful to circumvent the difficulties associated with the formulation design. The Rapid developments in the field of molecular biology and gene technology resulted in generation of many macromolecular drugs including peptides, proteins, polysaccharides and nucleic acids in great number possessing superior pharmacological efficacy with site specificity and devoid of unwanted and toxic effects. The oral cavity is highly acceptable by patients.  The mucosa is relatively permeable with a rich blood supply, it is robust and shows short recovery times after stress or damage.  The virtual lack of Langerhans cells makes the oral mucosa tolerant to potential allergens. Buccal drug delivery leads direct access to the systemic circulation through the internal jugular vein bypasses drugs from the hepatic first pass metabolism leading to high bioavailability. Buccal route is an attractive route of administration for systemic drug delivery. Buccal bioadhesive films, releasing topical drugs in the oral cavity at a slow and predetermined rate, provide distinct advantages over traditional dosage forms for treatment of many diseases.

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Post: Pharmacist

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