Andhra Pradesh

About Authors:
Kambham Venkateswarlu
Graduate Student
Sri Lakshmi Narasimha College of Pharmacy, Palluru,
Gudipala Mandal Chittoor-517132, Andhra Pradesh, India.
k.v.reddy9441701016@gmail.com

ABSTRACT:
In recent times, focus on plant research has increased all over the world and a large body of evidence has collected to show immense potential of medicinal plants used in various traditional systems. Over the last few years, rehears have aimed at identifying and validating plant derived substances for the treatment of various diseases. Similarly it has been already proved that various parts of plants such as Leafs, fruits, seeds etc. provide health and nutrition promoting compounds in human diet. The Bael (Aegle Marmelos) (L) Corr) is another Indian plant, which has enormous traditional uses against various diseases. The present review aims to compile medicinal values of Aegle Marmelos generated through the research activity using modern scientific approaches and innovative scientific tools.
It is called 'Shivadurme', the tree of Shiva, and is one of the sacred trees of the Hindus. Leaves are offered in prayers to Shiva and Parvathi since ancient times.

Company is the leading manufacturer of Active Pharmaceutical Ingredients (API) in the Cough and Cold segment along with a dominant presence in other therapeutic segments like Anti-histamines, Anti-convulsants, Anti-depressants and Anxiolytics (CNS) of the global pharmaceutical industry.

Post: General Manager-Unit Head (Manufacturing)

Company based in Tokyo, Japan is a research-based human health care (hhc) company that discovers, develops and markets products throughout the world. Company corporate human health care (hhc) mission is to give first thought to patients and their families, and to increase the benefits that health care provides. Pharmatechnology and Manufacturing Pvt. Ltd, a subsidiary of Co.

About Authors:
C.P.Meher
Asst. Professor
Maheshwara Institute of  Pharmacy,
Chitkul, Patancheru, Medak, A.P
chaitanyameher84@gmail.com

ABSTRACT
Pyrazole, a 5-membered heterocyclic diazole alkaloid composed of three carbon atoms and two nitrogen atoms in adjacent positions, is a prevalent scaffold in drug discovery programs. The aim of this review is to provide an overview of diverse pharmacological activities of pyrazole moiety.This review highlighted recent reports of antimicrobial, anticancer, ACE inhibitory, antiviral as well as anti-inflammatory activities of pyrazole. The purpose of this review was to collate literature work reported by researchers on pyrazole for their varoius pharmacological activities and also reported recent efforts made on this moiety.

About Authors:
C.P.Meher*, D.V.Charan, S.P.Sethy
Asst. Professor
Maheshwara Institute of  Pharmacy,
Chitkul, Patancheru, Medak, A.P
*chaitanyameher84@gmail.com

ABSTRACT
Heterocyclic chemistry is the branch of chemistry dealing with structure,synthesis, properties, and applications of heterocycles. heterocyclic compounds may be inorganic, most contain at least one carbon. Since in organic chemistry non-carbons usually are considered to replace carbon atoms, they are called heteroatoms, meaning 'different from carbon and hydrogen' (rings of heteroatoms of the same element are homocyclic). The IUPAC recommends the Hantzsch-Widman nomenclature for naming heterocyclic compounds.The present review article is based on the condenced heterocyclic system quinoline derivatives with their tremendous pharmacological activities.

Eisai Co., Ltd. based in Tokyo, Japan is a research-based human health care (hhc) company that discovers, develops and markets products throughout the world.

Eisai Co., Ltd. based in Tokyo, Japan is a research-based human health care (hhc) company that discovers, develops and markets products throughout the world.

About Authors:
Vijaya Kumar.Voleti*¹, Vaishnavi.V², V.Gunasekharan¹, M.S.Riyazullah¹, K.Vivekanandan^1
1Department of pharmaceutics, Rao’s College of Pharmacy, Nellore, Andhra Pradesh, India,
²Department of pharmaceutics, Sankar Reddy Institute of Pharmaceutical Sciences, Andhra Pradesh, India
*vijay66vvk@gmail.com

ABSTRACT:
Colon specific drug delivery has gained a more importance for the delivery at colonic region by use of various drugs to treat the both local and systemic diseases. Local diseases include Chron’s disease, ulcerative colitis, and colorectal cancer. Other serious disorders like nocturnal asthma, Hyper tension , arthritis and angina can also be cured by these techniques. Colonic delivery is a good candidature for delivery of proteins peptides and vaccines where the enzymatic degradation and the hydrolysis of proteins can be minimized and increases the systemic bioavailability. A drug should be protected from the absorption and the upper GI environment to achieve the successful colonic drug delivery. The colon specific delivery of drugs to the target receptor sites has the advantage to reduce the side effects and improves the therapeutic response. Colon specific drug delivery are being developed by taking advantage of the luminal PH conditions and the presence of microbial enzymes such as azoreductase, pectinase, dextranase…etc. This review mainly reveals on the various concepts and approaches include Prodrug, PH and time dependent systems and microbially triggered systems used in the development of colon specific drug delivery. This also focuses on the novel approaches namely Pressure controlled colonic delivery, osmotic controlled drug delivery and CODESTM. Invitro and in vivo evaluation parameters has been discussed here.