Uttar Pradesh

About Authors:
Garima Gupta*, Amit Singh
Department of Pharmaceutics,
R.V. Northland Institute,
Greater Noida, G. B. Nagar, U.P.
*Garima189@gmail.com

Abstract:
Technological attempts have been made in the research and development of rate-controlled oral drug delivery systems to overcome physiological adversities, such as short gastric residence times (GRT) and unpredictable gastric emptying times (GET). Conventional oral dosage forms pose low bioavailability problems due to their rapid gastric transition from stomach, especially in case of drugs which are less soluble at alkaline pH of intestine. Similarly, drugs which produce their local action in stomach get rapidly emptied and do not get enough residence time in stomach. So, frequency of dose administration in such cases is increased. To avoid this problem, various efforts have been made to prolong the retention time of drug delivery system. In this review, we will discuss about the various approaches to produce gastro retention of drug delivery system, with current & recent developments of Stomach Specific floating drug delivery system.

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ABOUT AUTHOR:
Kushwaha Anjali *
Naraina vidhya pith, faculty of pharmacy,
Gangaganj, Kanpur
* anjali.kushwaha1@gmail.com

ABSTRACT
Many traditional drugs when given orally exhibit poor and/or highly variable bioavailability and are often accompanied by significant gastro-intestinal side effects. The proprietary powder processing techniques developed by Nanotherapeutics improve the delivery of drugs that cannot normally be taken orally. Nanotherapeutics has developed new inhalation, nasal, injectable, and oral particle delivery systems that:

• Improve the safety and efficacy of low molecular weight drugs,
• Improve the stability and absorption of proteins that normally cannot be taken orally, and
• Extend the life cycle of many existing drug formulations.

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