Anti Inflammatory activity of methanol extract of Acacia leucophloea Roxb stem bark
About Authors:
Rajesh Gupta1*, Arun Kumar2, Aiswarya G3 , Santanu Roychowdhury1
1Department of Pharmacognosy,
Sri Sai College of pharmacy, Dalhousie road,
Badhani, Pathankot-145001,
Punjab, India.
2Department of Pharmacy,
BPS Mahila Vishwavidyalaya,
Khanpur Kalan, Sonipat
Haryana,India
3JDT Islam College of Pharmacy,
Vellimadukunnu, Calicut,
Kerala, India
ABSTRACT
The plant Acacia leucophloea Roxb is reported to have great medicinal value in Indian medicine. The present study deals with the preliminary phytochemical screening of Acacia leucophloea Roxb, stem bark in vivo evaluation of anti-inflammatory activity of methanol extract by using Carrageenan induced paw oedema and cotton pellet –induced granuloma model.The cotton pellet granuloma method is widely used to evaluate the transudative and proliferative components of the chronic inflammation. The moist weight of the cotton pellet correlates with the transuda; the dry weight of the pellet correlates with the amount of the granulomatous tissue. Administration of stem bark methanol extract at doses of 100 and 200 mg/kg b.w. and phenylbutazone (100 mg/kg b.w.) appears to be effective in inhibiting the dry weight of the cotton pellet. These data support the hypothesis of the greater effect of the extract on the inflammation mediators in the immediate response of inflammation in rats.
