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Pharmaceutics

  • FORMULATION AND IN-VITRO EVALUATION OF BUCCOADHESIVE TABLETS OF AN ANTIHYPERTENSIVE DRUG: ENALAPRIL MALEATE

    About Authors:
    DILIP KUMAR
    Department of Pharmaceutics,
    Rajiv Academy for Pharmacy, Mathura-286001, Uttar Pradesh, India

    kumardilip.pharma@gmail.com

    ABSTRACT:
    The aim of the present study was to prepare and evaluate buccal tablet comprising a drug-containing buccoadhesive layer and a drug-free backing layer, by the direct compression method. The mucoadhesive layer was composed of a mixture of drug, hydroxypropylmethylcellulose (HPMC K4M), Carbopol 934P (CP), Sodium carboxy methyl cellulose (NaCMC), and the backing layer was made of ethyl cellulose. Enalapril maleate is an ace -inhibitor was formulated onto buccoadhesive tablets to overcome the limitations in the currently available dosage forms and routes of administration which in sequence will increase patient’s compliance. Formulations (F1-F9) were developed and subjected to various evaluation parameters. All tablets were acceptable with regard to thickness, weight variation, hardness, and drug content. Maximum bioadhesive force was observed in tablets formulated using CP-NaCMC as a bioadhesive polymer (F4-F6). Formulation F6 showed maximum permeation of 91.98 % ± 0.58 in 8hr. Formulation F3 showed maximum swelling index of 2.99 ± 0.01 after 8hr. The mucoadhesive force and residence time of the optimized batch F6 are 0.14 N ± 0.01 and 9.10 hrs ± 1.15 respectively. The results indicate that suitable buccoadhesive tablets with desired properties could be prepared.

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