Aligarh

30 October 2012

INTRODUCTION TO STEM CELL CRYOPRESERVATION – A NEWER PHENOMENON OF ENSURING THE LONGEVITY OF CHILD HEALTH: A CLINICAL REVIEW

About Authors:
Mr. Satyanand Tyagi*, Raghvendra¹, Amlan Mishra², Patel Chirag J³, Asheesh Singh⁴
*President, Tyagi Pharmacy Association & Scientific Writer (pharmacy), Chattarpur, New Delhi, India-110074.
Prof. Satyanand Tyagi is a life time member of various pharmacy professional bodies like IPA, APTI and IPGA. He has published various research papers and review articles. His academic works include 51 Publications (43 Review Articles and 08 Research Articles of Pharmaceutical, Medicinal and Clinical Importance, published in standard and reputed National and International Pharmacy journals; Out of 51 publications, 11 are International Publications).
He has published his papers almost in different specialization of Pharmacy field...His research topics of interest are neurodegenerative disorders, diabetes mellitus, cancer, rare genetic disorders as well as epilepsy. ¹Department of Pharmaceutics, Aligarh College of Pharmacy, Aligarh, U.P, India-202001.
²Department of Pharmacology, Smt. Vidyawati College of Pharmacy, Jhansi, U.P, India-284128.
³Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020.
⁴Research Associate, Center for Research and Development, Ipca Laboratories Ltd Ratlam, Madhya Pradesh, India-457114.
*sntyagi9@yahoo.com, +91-9871111375 / 9582025220

ABSTRACT:
The umbilical blood cord being rich in stem cells needs to be preserved by means of a new technique called cryopreservation. The Process whereby whole tissues or cells are preserved by cooling at very low temperatures is known as Cryopreservation. Stem cell cryopreservation is a relatively new phenomenon; it is one way of ensuring the longevity of child’s health. This is done by banking the baby’s umbilical cord blood affluent with stem cells. Stem cells are important as they can grow into tissues, even organs like the heart or liver. What is more, they have the awesome potential to revamp damaged tissues.

Till date, over seventy diseases have been successfully treated with the help of stem cell stored in the cord blood. Research on stem cells has, by no means, abated. Scientists realizing their potential and worth are carrying out intensive research on their uses as well as ways preservation. Before preserving stem cells, a biological test is carried out to eschew the possibility of deadly diseases like various types of Hepatitis or HIV. That done, the cord blood cells are now stored by means of the technique under discussion- Cryopreservation. This technique involves adding a cryopreservant that lets the blood freeze gradually. The blood is frozen to sub-zero degree temperatures so that biochemical reactions or any other dangerous biological that could cause cell death may be arrested. Typically, the cells are stored at temperatures as low as -196, – 156, or – 120 degrees centigrade. Freezing stem cells through cryopreservation at such low temperatures is supposed to ensure their longevity. Let it be known, however, that scientists are still divided over the optimum temperatures as well as the efficacy of the cryopreservation technique itself. The aim of present article is to provide in depth knowledge about this technique of preserving stem cells of child i.e. the technique so called “Cryopreservation”. An attempt is also made to focus how this technique ensures the longevity of child’s health.
29 October 2012

Multiple vacancies in Indian Institute of Toxicology Research - Project Assistants & SRF | Walk in - 13 posts

The Indian Institute of Toxicology Research (IITR), established in 1965, a constituent laboratory of Council of Scientific & Industrial Research (CSIR) engaged in the Research & Development in the areas of Environmental Toxicology, Predictive Toxicology, Health Risk Assessment, Preventive Toxicology, Inhalation Toxicology, Analytical Toxicology, and also National S&T Missions. IITR has two campuses; the main campus is located at the centre of Lucknow City and the other campus at a distance of approx.
2 October 2012

TAK-875- A NEWER NOVEL ORAL TREATMENT FOR TYPE-2 DIABETES: A REVIEW

About Authors:
Satyanand tyagi^*, Raghvendra¹
*President, Tyagi Pharmacy Association & Scientific Writer,
Chattarpur, New Delhi, India-110074.
Prof. Satyanand Tyagi is a life time member of various pharmacy professional bodies like IPA, APTI and IPGA. He has published various research papers and review articles. His academic works include 45 Publications (37 Review Articles and 08 Research Articles of Pharmaceutical, Medicinal and Clinical Importance, published in standard and reputed National and International Pharmacy journals; Out of 45 publications, 10 are International Publications).
¹Department of Pharmaceutics, Aligarh College of Pharmacy,
Aligarh, U.P, India-202001.
*sntyagi9@yahoo.com, +91-9871111375 / 9582025220

ABSTRACT
Tak-875, a new treatment for type-2 diabetes, improves blood sugar control and is equally effective as glimepiride (Sulfonylurea, oral hypoglycaemic agent), but has a significantly lower risk of hypoglycaemia, according to a new study. It works by boosting the release of insulin from pancreatic beta cells when glucose and fatty acids rise in the blood, such as after a meal, which results in a fall in blood glucose levels. TAK-875 is a novel oral medication designed to enhance insulin secretion in a glucose dependent manner, which means that it has no effect on insulin secretion when glucose levels are normal, and as such has the potential to improve the control of blood sugar levels without the risk of hypoglycaemia. The pill belongs to a new class of treatments called GPR40 agonists, which activate a receptor that stimulates and regulates insulin production. New treatments are needed because of “the expected increase in the number of cases of Type 2 diabetes during the next few decades” and because some current drugs have “insufficient effect,” the researchers, led by Charles Burant at the University of Michigan Medical School, wrote in the study. Free fatty acid receptor 1 (FFA1), also known as G protein-coupled receptor 40 (GPR40), plays a vital role in stimulating and regulating the production of insulin. It works by boosting the release of insulin from pancreatic β-cells when glucose and fatty acids rise in the blood, such as after a meal. The release of insulin results in a fall in blood glucose levels. Drugs that activate the FFAR1 receptor have the potential to help diabetics release more insulin and improve control of blood glucose levels. This article gives an overview about this newly introduced drug TAK-875 and its role in treatment for type-2 diabetes.

(adsbygoogle = window.adsbygoogle || []).push({});
13 September 2012

PREPARATION AND EVALUATION OF BIODEGRADABLE ALBUMIN MICROSPHERES OF DICLOFENAC SODIUM

About Authors:
Renu^1*, Shashi Kant^2*, Rajendra Yadav³, Amit Kumar Tyagi⁴
¹Faculty of Pharmacy, Shivdan Singh Institute of Technology and Management, Aligarh (U.P)
²Jubilant Chemsys Ltd, Noida,
³Department of Pharmaceutical Sciences, Gurukul Kangri University Haridwar,
⁴Department of Chemistry, Meerut College, Meerut (U.P)
*shashi.pharma83@gmail.com

ABSTRACT :
Diclofenac is currently the eighth largest-selling drug and the most frequently used NSAID (Non-steroidal anti-inflammatory drug) in the world, since its introduction in Japan in 1974. Diclofenac is among the better tolerated NSAIDs. Only major adverse effect of Diclofenac is that it causes direct and indirect irritation of the gastrointestinal tract (GIT). To reduce the side effects on gastrointestinal tract (GIT) and to improve therapeutic efficacy of Diclofenac, it can be formulated in polymeric microspheres.
The use of polymeric carriers in formulations of therapeutic drug delivery systems has gained widespread application, due to their advantage of being biodegradable and biocompatible. Among the microparticulate systems, microspheres have a special importance since it is possible to target drugs and provide controlled release. Diclofenac sodium (DS), is a potent drug in the NSAID group having non-steroidal, anti-inflammatory properties, and is widely used in the treatment of rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. In this present study, it was aimed to prepare microsphere formulations of DS using a natural biodegradable polymer as a carrier for administration to extend the duration period of the dosage form. Microsphere formulations of DS which were prepared were evaluated in vitro for particle size, yield value, encapsulation efficiency, surface morphology, and in vitro drug release.
11 July 2012

Opportunity for freshers to work in Olefia Biopharma as Marketing Executives - 13 posts

Olefia Biopharma Limited, We would like to introduce ourselves as one of the most rapidly emerging FMCG Company in various fields of Pharmaceutical, Cosmetics, Ayurvedics / herbals and biotech.
27 May 2012

BIOCATALYSIS IN ORGANIC SOLVENT SYSTEM

About Authors:
Chhavi Bartaria^*, Javed Ali Khan
Institute of Biomedical Education and Research,
Mangalayatan University,
Aligarh.
*cbartaria@gmail.com

Abstract
Biocatalysis involving certain enzymes like NHase, Nitrilase, Tannase and Amidase produces certain commercially important compounds .NHase are used for the synthesis of certain compounds such as acrylamide and nicotinamide. Thermostable Nitrilase from the Rhodococcus strains is used for the modification of acrylic fiber surface. The activity of amidase enzymes is five times increased and inhibited with the use of Co²⁺and Hg^2+, 2-mercaptoethanol, dithiothreitol, and ethylene diaminetetraceticacid respectively. Furthermore the production of amidesis done as a by the help of a nitrilase-catalysed reaction of a heterolytic amino nitriles by a enzyme. For the hydrolysis of Gallic acid esters and hydrolysable tannis the tannase is use as catalyst and this gallic acid is produced by the hydrolysis of methyl gallate by fungal tannase, the tannase activity is also shown by lactic acid bacteria and the nitrilase is used for the modification of acrylic fibers by the help of a reaction media with some parameters like time, enzyme activity and its formulation.
11 November 2011

Multiplace vacancies in Ahlcon Parenterals India | Require Sales Manager, Tewrritory Sales Manager
7 September 2011

Walk in : Post for Sales Officers, District Managers, Regional Sales Managers & Zonal Sales Managers in Ajanta Pharma

Ajanta Pharma Limited is an emerging, global pharmaceutical company with proven capabilities in the areas of product research, manufacturing & marketing.
26 May 2011

Walk in : Systopic Labs invites for post of Trainee Medical Representative | Lucknow, Delhi, Hissar, Aligarh

Systopic is an established pharmaceutical organization with an enterprising field force of 750, we believe in Nurturing Talent & help our people grow. A befitting remuneration package along with one of the best incentive schemes ensures that performers are appropriately rewarded.
4 April 2011

Work as Medical Representative in Baidyanath - 20 vacancies

One of Indias most respected Companies, Shree Baidyanath Ayurved Bhawan p Ltd. Kolkata, popularly known as Baidyanath, is the acknowledged leader of Ayurvedic know-how. Established in 1917, the Company has played a pioneering role in re-establishing ancient knowledge with modern research and manufacturing techniques.