Karnataka

About Authors:
KALPESH PATEL, JAYACHANDRAN E.*, SREENIVASA G.M.
* P.G. Department of Pharmaceutical Chemistry,
S.C.S. College of Pharmacy, Harapanahalli-583131,
Karanataka, India.
*drjc_2006@rediffmail.com, kalpesh.m.pharm@gmail.com

Abstract
Various substituted 3-amino-1-(2,4-dinitro phenyl)-5-[(5-substituted-1,3,4-oxadiazol-2-yl)amino]-1-H-pyrazole-4-carboxyamide and (5E)-5-[4-(dimethylamino) benzylidene]-3-(5-substituted-1,3,4-oxadiazol-2-yl)-2-phenyl-3,5-di hydro-4H-imidazol-4-one have been synthesised and evaluated for antiinflammatory activity. Structure of these products has been established by IR, ¹H NMR data. Significant activity were observed for some members of the series.

About Authors:
Megana.H.S*, A.Satish Kumar Shetty, Anil Kumar S.M
*Department of Pharmaceutical Analysis,
National College of Pharmacy, Balraj Urs road,
Shimoga-577201,
Karnataka, India.
megana.leo@gmail.com

ABSTRACT
A novel, accurate, precise, sensitive, economic and rapid spectrophotometric methods has been developed and validated for simultaneous estimation of Triamterene and Benzthiazide in bulk and pharmaceutical dosage form. Triamterene and Benzthiazide showed absorption maxima at 363 nm and 283 nm in ethanol, which is used as solvent. In the present study, Area Under Curve method (Method A) developed, employedthe measurement of area at selected analytical wavelength ranges. Two analytical wavelength ranges selected were 358nm to 368nm nm (lmax of Triamterene is 363nm) and 278nm to 288nm (lmax of Benzthiazide is 283nm) for the estimation of Triamterene and Benzthiazide respectively.  Ratio derivative method (Method B) employed the measurement of amplitudes of Triamterene and Benzthiazide at their respective selected wavelengths. Two wavelengths selected were 359.2 nm and 300.4 nmfor the estimation of Triamterene and Benzthiazide respectivelybased upon divisor method.  Linearity was observed in the concentration range of 6-30 μg/ml and 3-15 μg/ml for Triamterene and Benzthiazide respectively. The recovery studies ascertained the accuracy of the proposed method and the results were validated as per ICH guidelines.

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About Authors:
YASWANTH ALLAMNENI^1*, PAVAN POTTURI¹, RAJKUMAR NULU², RAVADA RAMESH³, P DAYANANDA CHARY¹, ARUN KALEKAR¹.
¹Research and Development Department, Natco Pharma Limited, Kothur, Mahaboobnagar,Andhra Pradesh, India-509228.
²Research and Development Department, Aurobindo Pharma Ltd., Hyderabad, Andhra Pradesh, India.
³HOD, Dept. of Pharmaceutics, Dr. H.L.T. College of pharmacy, Kengal, Channapatna, Banglore(R).
*yaswanthallamneni@gmail.com

ABSTRACT
The aim of this study was to investigate the influence of superdisintegrants on the dissolution properties of a poorly water-soluble drug from complexes prepared by kneading method. Ketoprofen was employed as a model drug. Solid dispersions prepared by kneading method exhibited higher dissolution rate and DE30 values in each case. Ketoprofen tablets were prepared by direct compression technique using microcrystalline cellulose as a directly compressible vehicle. The formulated tablets were evaluated by different In Process Quality Control tests, content uniformity and in vitro drug release study. The FTIR spectra’s study revealed that there were no interaction between polymers and drug. All the tablets formulated employing solid dispersions in superdisintegrants gave rapid and higher dissolution of Ketoprofen when compared to that of Ketoprofen plain tablets. Ketoprofen dissolution from all the tablets followed first order kinetic with correlation coefficient ‘r’ above 0.9470. All dissolution parameters (k₁, DE₃₀ and T₃₀) indicated rapid and higher dissolution of Ketoprofen from tablets formulated employing its solid dispersions in superdisintegrants when compared to plain tablets.

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