Karnataka

About Authors:
HH SAPARIA*, M BAIDYA, AR MAHESH
Krupanidhi College of Pharmacy, Chikkabellandur, Carmelaram Post,
Varthur  Hobli, Banglore-560035, Karnataka, India.
*hiteshsapariya29@gmail.com

Abstract:
Current advancement in drug discovery technology and search for novel chemical diversity have  intensified the efforts for exploring lead from “Ayurveda”  the traditional  system of medicine in India. Lantana camara, Family: Verbenaceae has been important coniferous plant in ayurvedic and indigenous medicinal systems. The Clinical trials and  animal research support  the use of Lantana camara for anti-spasmodic, carminative, anti-tumour, anti-inflammatory, anti-malarial, anti-ulcer genic, treatment of emotional stress and trauma, anti-microbial, insecticidal, fungicidal, asthma. Major biochemical constituents of Lantana camara were identified as alkaloids/flavonoids, saponins/tannins, germacrene-A, B and D, triterpenes like lantadenes-A, B, C, D, valencene (principle constituent) and γ-gurjunene, verbascoside, martynoside.This paper includes the evidence-basedoverview of pharmacological and phytochemical properties of the aerial parts of Lantana camara.

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About Authors:
A.D.Taranalli, Dilip Patoliya*, Sonal Chanchlani, Vishal Patel, Keyur Makadiya
Department of Pharmacology and Pharmacokinetics,
K.L.E. University’s College of Pharmacy, Belgaum.
*Dilip_patoliya@yahoo.com

ABSTRACT:
Ulcerative colitis is a chronically recurrent inflammatory bowel disease of unknown origin in which oxidative stress has been implicated. The main aim of the present study was to evaluate possible protective effect of alcoholic extract of Aloe Vera against the drug induced model of colitis in rats. Induction of colitis by colonic administration of drugs(Acetic acid, Indomethacin and TNBS) cause severe microscopic inflammation of colon after 24 hrs of administration of one of any above  inducing agent, as assessed by the macroscopically. Microscopically colonic tissue showed ulceration, oedema and inflammatory cell infiltration. Biochemical estimation studies revealed decrease in serum levels of lactate Dehydrogenase (LDH) may be due to increase in Colonic concentration of tumor necrosis factor α (TNF- α) and neutrophill infiltration index. Oxidative stress was indicated by reduced glutathione concentration (GSH) as well as increase in levels of lipid peroxidase (LPO) and myeloperoxidase (MPO) activity in colonic tissue. Pretreatment with Aloe Vera extract at a dose of (400mg/kg/day, orally),10 days before induction of colitis increase level of serum LDH and GHS, while colonic concentration of LPO and MPO was increased. It also showed decrease in macroscopic score. The findings of the present study provide evidence that Aloe Vera extract may be beneficial in inflammatory bowel disease.

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About Authors:
S. Mahboob Ahmad, T.S Gouda
V.L. College of pharmacy,
Raichur, Karnataka-58410
*syed.ahmad007@yahoo.com

Abstract:
The alcoholic and aqueous extracts of fruit of Carica papaya (Caricaceae)was investigated for anti-diarrhoealactivity in albino Wistar rats. The alcoholic and aqueous extracts was administered by the oral route at a concentration of 100, 200 and 400 mg/kg showed the significant dose dependent anti-diarrhoeal activity in Castor oil induced diarrhea and Magnesium sulphate induced diarrhea. Anti-diarrhoeal activity of the tested extracts was comparable with that of the standard drug Loperamide 3 mg/kg. The results lend support to the traditional use of C.  papaya in the treatment of diarrhoeal diseases.