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Research News

  • Insights into causes of rare genetic immune disorders Pradip Mahajan Thu, 03/23/2023 - 17:03

    The cellular glitches underlying a rare genetic disorder called activated PI3K Delta syndrome 2 (APDS2) have been identified by researchers at the Garvan Institute of Medical Research. The disorder is caused by genetic variations that disrupt immune cell signalling through a protein called PI3K.

  • Biomarkers Show Promise for Identifying Early Risk of Pancreatic Cancer Pradip Mahajan Tue, 03/21/2023 - 16:58

    A research team at Duke Health has identified a set of biomarkers that could help distinguish whether cysts on the pancreas are likely to develop into cancer or remain benign.

    Appearing online March 17 in the journal Science Advances, the finding marks an important first step toward a clinical approach for classifying lesions on the pancreas that are at highest risk of becoming cancerous, potentially enabling their removal before they begin to spread.

  • New combination of drugs works together to reduce lung tumors in mice Pradip Mahajan Tue, 03/21/2023 - 16:52

    Cancer treatments have long been moving toward personalization finding the right drugs that work for a patient’s unique tumor, based on specific genetic and molecular patterns. Many of these targeted therapies are highly effective, but aren’t available for all cancers, including non-small cell lung cancers (NSCLCs) that have an LKB1 genetic mutation.

  • Resistant bacteria are a global problem, researchers may have found the solution Pradip Mahajan Mon, 03/20/2023 - 16:25

    A new substance has proven useful for treating staphylococcus infections in people with skin lymphoma. This is good news for the patients, but also for the global threat of antibiotics resistance.

  • Molecular Component of Caffeine May Play a Role in Gut Health Pradip Mahajan Mon, 03/20/2023 - 16:15

    The gut is home to a cast of microbes that influence health and disease.

  • Large-scale study enables new insights into rare eye disorders Pradip Mahajan Mon, 03/13/2023 - 16:32

    Researchers have analysed image and genomic data from the UK Biobank to find insights into rare diseases of the human eye. These include retinal dystrophies – a group of inherited disorders affecting the retina – which are also the leading cause of blindness certification in working-age adults.

  • New insights into how patient factors and COVID-19 infection affect antibody responses in people with HIV

    People with HIV have impaired immune responses to some pathogens and immunizations, and during the COVID-19 pandemic, they often experienced severe symptoms if infected with SARS‐CoV‐2.

  • Two-pronged immunotherapy eliminates metastatic breast cancer in mice

    Researchers at Washington University School of Medicine in St. Louis have identified a way to sensitize metastatic breast cancer that has spread to bone to immunotherapy. Shown are two bones from mice with metastatic breast cancer. Tumors are inside the yellow outline. The left side shows an untreated tumor. The right side shows a tumor treated with a p38MAPK inhibitor. The increased green color on the right indicates the tumor is more sensitive to immunotherapy.

  • Study Examines Heart Inflammation after COVID Vaccine

    “To our knowledge, this is the first prospective study to report comprehensive cardiac investigations and imaging in both symptomatic and asymptomatic patients after COVID-19 vaccination,” said the study’s senior author Kate Hanneman, M.D., M.P.H., associate professor in the Department of Medical Imaging and director of cardiac imaging research at the University of Toronto in Toronto, Canada.

  • Fresh understanding of ageing in the brain offers hope for treating neurological diseases

    Scientists from the Trinity Biomedical Sciences Institute (TBSI) have shed new light on ageing processes in the brain. By linking the increased presence of specialised immune cells to conditions such as Alzheimer’s disease and traumatic brain injury for the first time, they have unearthed a possible new target for therapies aimed at treating age-related neurological diseases.

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