Punjab

PREPARATION AND EVALUATION OF RIVASTIGMINE NANOPARTICLES FOR TREATMENT OF DEMENTIA ASSOCIATED WITH ALZHEIMER’S DISEASE

About Authors:
Bajaj L.*, Chopra D.1
*PCTE Institute of Pharmacy, Jhandey, Ludhiana-142021, Punjab, India.
1Department of Pharmaceutical Sciences and Drug Reasearch,
Punjabi University. Patiala.
*lotika.bajaj@gmail.com / lotika@pcte.edu.in

Abstract
Alzheimer’s Disease is a neuropathological disorder that causes dementia by progressively degenerating the neurons that are responsible for learning and memory processes. Rivastigmine has demonstrated favorable efficacy and safety in patients with dementia. Nanostructure mediated drug delivery enhances drug bioavailability, improves the timed release of drug molecules, and enables precision drug targeting. Because of its cationic charges, biocompatibility, and low toxicity, chitosan has been used as a vehicle system for genes, protein and drugs. The present study has been undertaken to investigate the targeted delivery of rivastigmine loaded chitosan nanoparticles in streptozotocin induced dementia in mice. Rivastigmine loaded chitosan nanoparticles were prepared by ionic gelation method. The nanoparticles were evaluated for size, shape, zeta potential, microscopy, transmission electron microscopy. Drug-polymer compatibility was determined using differential scanning calorimetry. The amount of drug entrapped within the nanoparticles was determined spectrofluorometrically and in vitro drug release studies were done by spectrofluorometer. Morris Water Maze Test was used to evaluate in vivo activity of rivastigmine nanoparticles in mice. The mean hydrodynamic diameter of chitosan nanoparticles prepared was found to be 258 nm with  positive zeta potential value of about 35.1 mV. The entrapment efficiency for various batches of rivastigmine nanoparticles showed a range of 42-84% w/w. Prolonged drug release was observed in case of chitosan nanoparticles. The best release pattern was seen in case of batch A with 1:1 drug : polymer ratio. Rivastigmineloaded Chitosan nanoparticles were found to be effective in STZ induced dementia in mice.

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Thapar University (TU) was established on 8 October 1956 as an Engineering College named Thapar Institute of Engineering and Technology. It is a University established in 1985 vide Sec.3 of the UGC Act, 1956 under notification # F.9-12/84-U.3. Thapar University offers Post-graduate and undergraduate programs in Engineering, Science, Management and Social Sciences.

Aegle marmelos: A phytochemical and phytopharmacological review

ABOUT AUTHORS
Junaid Niazi1*, Yogita Bansal2, Narinderpal Kaur3
1 Asst.Prof., Bahra Institute of Pharmacy, Patiala, India
2 Assoc. Prof., Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, India
3 Asst. Prof., Baddi University of Emerging Sciences and Technology, Baddi, India

* niazi.junaid@yahoo.co.in

ABSTRACT
Aegle marmelos
Corr., a deciduous aromatic tree has been recognized in traditional medicine for the treatment of different diseases and ailments of humans like dysentery, fever, diabetes, asthma, heart problems, ophthalmia, haemorrhoids urinary problems etc.  The plant has been reported to contain several phytoconstituents belonging to category of coumarins (like marmenol), alkaloids (like aegeline), glycosides, triterpenoids, anthraquinones, sterols and volatile oils. Several modern scientific studies have authenticated its anti diarrhoeal and gastro protective, anti diabetic, antibacterial, analgesic, anti-inflammatory, antioxidant, anti thyroid, anti histaminic, anti prolifertive and anti fertility activity. Clinical trials of a formulation Diarex (containing A. marmelos has shown positive results patients suffering from diarrhoea and dysentery. This review gives a bird’s eye view mainly on folkloric uses, phytochemistry and pharmacological actions of the plant.

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