Sai Kushal Gunturu*, Tulasi Ram Nayak Menavath, Ramadoss Karthikeyan
Vignan Pharmacy College, Vadlamudi-522213, Guntur, Andhra Pradesh, India
Nitrosamines belongs to a family of potent carcinogenic substances that have been rigorously stidie dover the past decades due to its extreme carcinogenic nature to animals as well as humans. It is generally found as an industrial contaminant but can also the exposure to the substance maybe due to soil, water or food contamination. The carcinogenicity to humans is caused by the metabolised product of nitrosamines especially, N-nitroso compounds.
One of the most extensively studied compound of this fami.ly is N-Nitroso dimethylamine due to its potency in the formation of cancers. N-Nitroso dimethylamine induces cancers in the stomach due to its metabolism in the gut and the production of toxic metabolites. Frequently N-Nitroso dimethylamine exposure is via skin absorption and also via ingestion.
Under extensive researches in mice, in oral administration it is found to induce cancers of lung, kidney and stomach. It was proposed that the toxic nature of N-Nitroso dimethylamine is due to the highly – oxygen reactive species forming metabolite nature and also altering the activity of liver microsomal enzymes.