Gulbarga

PHARMACODYNAMIC INFLUENCE OF VITAMIN E AND ESOMEPRAZOLE ON GASTRO PROTECTION IN PYLORUS LIGATION INDUCED ULCERS IN RATS

About Authors:
NITIN M, MOHAN REDDY U*
Department of Pharmacology,
H.K.E.S’s, Matoshree Taradevi Rampure Institute of Pharmaceutical Sciences,
Sedam Road, Gulbarga- 585 105, Karnataka
*mohanreddy.udumula@gmail.com

ABSTRACT
Gastric ulcer is one of the most prevalent gastrointestinal disorders, which affects approximately    5-10% of people during their life. The present study was aimed to find out the pharmacodynamic influence of vitamin E and esomeprazole and their combination on gastro intestinal parameters in pylorus ligation induced ulcers in rats in single and multiple dose studies.  Various parameters were studied in  pylorus ligation induced ulcer model viz. gastric volume, pH, total acidity, free acidity, and ulcer index.The antiulcer effect of the combination of vitamin E 0.9 mg/200 g and esomeprazole 0.54 mg/200 g b.w orally was compared with the reference standard esomeprazole 0.54 mg/200 g b.w orally. The ulcer index was calculated and other biochemical parameters of gastric juice were estimated. The ulcer index of combination showed significant (P < 0.05) reduction while other biochemical parameters like volume, pH, free acidity and total acidity of gastric juice showed highly significant (P < 0.001) reduction when compared to control and standard esomeprazole.

PHARMACOECONOMIC EVALUATION OF ANTI-DIABETIC THERAPY AT BTGH, GULBARGA

ABOUT AUTHORS:
Shujauddin Hashmi*,P. Neelkant reddy, S. hafiz ali, B. Kalyani, K. Karna, S. S.Biradar, Abdul kareem
Department of pharmacy practice
H.K.E Society’s Matoshree Taradevi Rampure Institute of Pharmaceutical Sciences,
MR medical College Road, Gulbarga -585105

ABSTRACT
Diabetes mellitus is a chronic and potentially disabling disease which is like a sleeping giant that is ready to awaken and literally sink our health care system. The present study “Pharmacoeconomic evaluation of anti-diabetic therapy” was carried out with an objective to assess estimated direct medical cost of diabetes and its complications. A hospital based prospective observational study was conducted using a prevalence based ‘cost of illness’ method focusing on estimated direct health care cost of diabetes and its complications. A total of 108 type 2 DM patients were enrolled into the study out of which 68 (62.96%) were males and 40 (37.04%) patients were females. The results revealed that, the average cost was the highest for the age group 45-60 years. The costs for patients with complications were substantially higher than those without complications and the costs were found to increase progressively with the increase in number of complications. The study concludes that Diabetes with complications resulted about 2.5 times higher cost, therefore the burden of diabetes and its complications was significant for individual and families, keeping in mind the burden of the disease on individuals as well as the society, the health policy makers should emphasize on initiatives to prevent the disease prevalence, care and counseling to diabetes patients should be done continuously to prevent the progression of the disease and its devastating complications.

NEED OF PHARMACOECONOMICS IN INDIAN HEALTH CARE SYSTEM: A BRIEF REVIEW

About Authors:
Hinchagri S S 1*, Halakatti P K2,  Devar S B2, Biradar B S2, Kankanwadi S K2, Patil S D2
1. HKES’s College of Pharmacy, Sedam Road, Gulbarga, Karnataka, India
2. HSK College of Pharmacy, BVVS’s Campus, Bagalkot, Karnataka, India

*shivanand.hinchageri95@gmail.com

Abstract:
In India, nearly 3.1 million households below the poverty line and those are unaffordable for private health care. Cost of medicines are growing constantly as new medicines are marketed and are under patent law, preference of drug therapy over invasive therapy, and the irrational drug prescription. In a developing country like India 85% of total health expenditure is financed by house-hold, out-of–pocket expenditure. The proportion of insurance in health-care financing in India is very low. Many poor people frequently face a choice between buying medicines or buying food or other necessities due to limited resources and high pricing of drug. So medicine prices do matter. The main objective of study is to show the importance of pharmacoeconomic evaluation in Indian health care. Methods to be used for pharmacoeconomic evaluation are Cost-effectiveness analysis, Cost minimization analysis, Cost-benefit analysis and Cost-utility analysis. Review of pharmacoeconomic evaluation sample studies shows the pharmacoeconomics became more important 1. To find the optimal therapy at the lowest price. 2. Numerous drug alternatives and empowered consumers also fuel the need for economic evaluations of pharmaceutical products. 3. The use of economic evaluations of alternative healthcare outcomes. 4. Healthcare resources are not easily accessible and affordable to many patients; therefore pharmacoeconomic evaluations play an important role in the allocation of these resources. The study concludes that in India the pharmacoeconomic evaluation is essential to optimal therapy at lowest price, alternative treatment plans, which help the poor and middle class Indians to obtain well health care services.

Evaluation of Antihyperglycemic Activity of a Polyherbal Formulation in Alloxan induced Diabetic Rats

ABOUT AUTHORS:
S Hamza*, Dr D. K. Suresh, R. Hasan, Md S. Khalid, R. Mistry
Department of Pharmacology,
Luqman College of Pharmacy,
Gulbarga - 585 102,
Karnataka, India.

ABSTRACT:
The study was to assess the antidiabetic activity ofa polyherbal formulation in alloxan induced diabetic rats. The antidiabetic activity of a polyherbal formulation in alloxan induced diabetic rats was assessed using Alloxan β-cytotoxin induced chemical diabetes in a wide variety of wistar albinorats. The polyherbal formulation contains thefollowing plants leaves of Gymnema sylvestre, Ginkgo biloba and plant seeds of Mucuna prurience.The extracts were prepared by continues hot soxhlet extraction using petroleum ether and water. Three different formulations were prepared for the study. The study reveals that the polyherbal formulations of plants leaves of Gymnema sylvestre, Ginkgo biloba and plant seeds of Mucuna prurience have antidiabetic activity and theactionmay be due to the restoration or regeneration of β-cells of pancreas.

EFFECT OF RHIZOBIUM SEED INOCULATION AND NITROGEN FERTILIZER ON THE GROWTH OF GREEN GRAM, BENGAL GRAM AND GROUNDNUT CROPS

About Authors:
Dr. M.B.SULOCHANA, PRASHANTH GADGI
Department of Biotechnology,
Gulbarga University,
Gulbarga, Karnataka,India

ABSTRACT
To determine the effect of rhizobium inoculation and nitrogen fertilizer on performance of Green gram, Bengal gram and Groundnut. Investigations were done in pot culture experiment under natural conditions. The research material consists of Green gram, Bengal gram and Groundnut varieties with treatment of seeds and Nitrogen fertilizer at 60kg/ha for green gram and Bengal gram, 120kg/ha for Groundnut. These treatments were compared against control (no inoculation). Data were recorded on Plant Growth parameters (seed germination, nodulation index, plant height at maturity, wet weight and dry weight) and soil nitrogen levels at the end of experiment. Among all treatments plant with seed inoculation was found effective in all three legume varieties compared to soil with nitrogen fertilizer and control.

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