Gujarat

It is proposed to engage full time Para Medical staff for the following posts purely on contract basis on BCT Division of Western Railway. The details of the post, place of posting, remuneration etc. and other terms and conditions stipulated are given below:-

About Authors:
*Thoriya J. G, Patel S. D, Tank H. M
Matushree V. B. Manvar College of Pharmacy- Dumiyani,
Rajkot
*thoriya.jignesh@gmail.com

ABSTRACT
Pioglitazone HCl is used for the management of type-2 diabetes. It is an absorption window limited drug, whose solubility decreases with increase in the pH and has a short half life of 3-7 h. Here an attempt is made to developed the floating matrix tablets, which design in way that after oral administration the GI resistant time is  prolonged and thus to give sustained action with increase in the bioavailability of the drug. Pioglitazone HCl showed maximum absorption at wavelength 269 nm in 0.1N HCl. various formulations were developed by using release rate controlling and gel forming polymers like HPMC, and Carbopol-934 in single and combinations by direct compression method with the incorporation of sodium bicarbonate as gas generating agent. The prepared tablets were characteristics by drug content, floating property, swelling and in vitro dissolution test using USP dissolution test apparatus Type – II (paddle method) in dissolution medium of 0.1 N HCl. The in vitro dissolution results of all tablets were computed by using dissolution software. The prepared tablets were found to be good hardness, diameter, weight variation, thickness, friability drug content, floating property and in vitro drug release. Drug-polymer compatibility studies by FTIR gave conformation about drug purity and showed no interaction between drug and selected polymers. All the formulations had floating lag time below 3 minutes and constantly floated on dissolution medium for more than 12 h. Swelling studies indicated significant water uptake and contributed in drug release. From among all the developed formulations, as F7 prolonged the drug release (95.45 %) for longer period of time (12 hrs.); they were selected as best formulations. The best formulations were found to be stable during stability studies for two months. Thus, selected formulations satisfied floating time, swelling index and in vitro drug release profile requirements for a floating drug delivery system.Tablets of Pioglitazone HCl prepared with HPMC K4M, HPMC K100M and Carbopol 934P were found to be acceptable floating property, water uptake and in vitro drug release.

About Authors:
Vedant Pandya
M.Sc. Biotechnology,
Department  Of  Biotechnology,
Shree M.N.Virani Science College, Rajkot
vedantpandya007@gmail.com

Abstract :
The potential of Cosmarium species, belonging to green Micro algae, was investigated as a viable biomaterial for biological treatment of triphenylmethane dye, Malachite Green (MG).  This can be used for the bioremediation of dye effluents. The results obtained from the batch experiments revealed the ability of algal species in removing dye.  The effects of operational parameters (temperature, pH, dye concentration and algal  concentration) on decolorization were examined.  The stability and efficiency of the algae in long-term repetitive operations were also examined. Michaelis–Menten kinetics was used to describe the apparent correlation between the decolorization rate and the dye concentration.

[adsense:336x280:8701650588]

About Authors:
Kalpen N. Patel*, Maulika S. Patel, Divya Thakkar, Manan Patel, Kaushal Raval
Shree Krishna Institute of Pharmacy, Shankhalpur,
Bechraji, Mahesana, Gujarat, India.
*kalpenpharma@gmail.com

ABSTRACT
Sustained releases tablets have been used for reduced the dosing frequency and maintain the plasma drug concentration level within narrow therapeutic range. Aspirin used as antiplatelate agent and Atorvastatin is HMG-CoA reductase inhibitor which lowers the plasma concentration of cholesterol. Here in present study sustained release tablets of Aspirin and Atorvastatin prepared by using cellulose acetate phthalate (CAP) and microcrystalline cellulose (MCC) as a polymers. The sustain release tablet of Aspirin And Atorvastatin were prepared by wet granulation method and were substituted for film coating to mask the spotting from Atorvastatin and for protection from light. From the dissolution profile of F2B2 gives controlling the release up to 12 hrs with required value i.e. - 55.85 % for Aspirin and 54.78 % for Atorvastatin in 4 hrs respectively and 100.70 % for Aspirin and 100.60 % for Atorvastatin in 12 hrs respectively. The result of stability studies of batch F2B2 indicate that it is stable at 400C / 75 % ±0.5 % relative humidity as there was no significant differences observe for dissolution and average drug content data after two months.

About Authors:
Ritesh Shah*, Gaurav Chandawat, Rahul Jadav, Bhoomi Arora
Institute Of Clinical Research (India),
Ahmedabad, Gujarat-380013, India
*ritesh_shah99@yahoo.com

ABSTRACT
Venous thromboembolism (VTE) complicates approximately 1 to 2 of 1,000 pregnancies, with pulmonary embolism (PE) being a leading cause of maternal mortality and deep vein thrombosis (DVT) an important cause of maternal morbidity. The main reason for the increased risk of thromboembolism in pregnancy is hypercoagulability, which has likely evolved to protect women from the bleeding challenges of miscarriage and childbirth. Women are at a 4- to 5-fold increased risk of thromboembolism during pregnancy and the postpartum period compared with when they are not pregnant. Eighty percent of the thromboembolic events in pregnancy are venous, with an incidence of 0.61 to 1.72 per 1000 pregnancies.Includes a history of thrombosis, inherited and acquired thrombophilia, maternal age greater than 35, certain medical conditions, and various complications of pregnancy and childbirth.

Despite the increased risk of VTE during pregnancy and the postpartum period, most women do not require anticoagulation. The intensity of the anticoagulation will depend on the indication and the monitoring will depend on the intensity. At the time of delivery, anticoagulation should be manipulated to reduce the risk of bleeding complications while minimizing the risk of thrombosis. There are no large trials of anticoagulants in pregnancy, and recommendations are based on case series, extrapolations from nonpregnant patients and the opinion of experts. Nonetheless, anticoagulants are believed to improve the outcome of pregnancy for women who have, or have had, VTE.

Leading Medical device company at Ahmedabad [Gujarat]

Post: Sr. Manager - Production

[adsense:336x280:8701650588]

About Authors:
Alpesh J.Shiroya*, K.K.Vaghasiya, N.J.ghantala
Bhagwan Mahavir College Of  Biotechnology ,
Surat
*alpeshshiroya45@yahoo.in

Abstract
Clean technology has become an important concern for every industry. Especially in textile dyeing factories, there is much use of water, energy, dyeing colours and chemicals. This can cause significant water and air pollution problems. The wastewater wear a lot of colour and having toxic odour, COD and BOD. wastewater contains the following reactive dyes: turquoise DG, black DN, red DB-8 and orange OGR. It has been shown that the efficiency of dye removal depends on the type of dye, coagulant dosage, and the sample pH.The performance of COD and colour removal in the single-stage ozonation- biological treatment was also compared with the multi-stage ozonation-biological treatment processes. Ozonation transforms the functional groups in azo dye to produce more biodegradable by products, which is easily removed by biological treatment. semiconductor photocatalysis process could be an appropriate tool for the treatment for textile dyeing and printing wastewater. Activated sludge treatment and the coagulation-flocculation method with ≥80% removal efficiency of waste water. Using the electrocoagulation process possible the reuse of dye wastewater by removing the colours. sequential batch reactor (SBR) technology as an alternative method for treating industrial effluents.In the present work we review existing processes as well as promising new technologies for texttile waste water decolorisation.

Torrent Pharmaceuticals Limited, is a dominant player in the therapeutic areas of cardiovascular (CV) and central nervous system (CNS) and has achieved significant presence in gastro-intestinal, diabetology, anti-infective and pain management segments.

About Authors:
Pankaj S. Waghere^1*, Malpani Amol²,
1Prin. K. M. Kundnani College of Pharmacy, Mumbai. Maharashtra, India.
2Roland Institute of Pharmaceutical Sciences, Berhampur. Orissa, India.
*waghere.pankaj@gmail.com

ABSTRACT
Hydrocolloids are naturally-occurring plant polysaccharide, in that gaur gum is most useful and validated natural plant polysaccharide. Guar gum and their derivatives are widely used in pharmaceutical dosage forms. Many are used as biodegradable polymeric materials to deliver active pharmaceutical ingredients. Natural polymers can be modified to obtain tailor-made materials for drug delivery systems and to compete with the synthetic biodegradable excipients available in the market. Natural polymers as a drug carrier material are of two types: polysaccharides and proteins. They found both in plants and animals providing several advantages over synthetic polymers.Gaur gums are preferred to those of synthetic origin due to their green, cost-effectiveness, nontoxic, easy availability and for suitable binder in tablet manufacture. The aim of this review is to provide an insight into the many potential applications of gaur gum as pharmaceutical natural excipients.