Rajasthan

UV SPECTROPHOTOMETRIC DETERMINATION OF OLMESARTAN MEDOXOMIL IN PURE AND PHARMACEUTICAL FORMULATION

ABOUT AUTHORS
PANDIYA HARSHADA*, RATHORE KS
Department of Pharmaceutics, B.N. College of Pharmacy, BN University, Udaipur- 313001

ABSTRACT
Olmesartan medoxomil (OM) is a new angiotensin II receptor antagonist agent. Olmesartan medoxomil is a prodrug, which, after ingestion, liberates the only active metabolite, olmesartan. Simple and sensitive method has been developed for determination of olmesartan medoxomil in both pure and pharmaceutical formulation. This method obeys Beer’s law in the concentration range of 15-55 µg/ml, exhibiting maximum absorption at 258.10 nm. In this method no interference from the common pharmaceutical excipients was observed. The developed and validated method was applied for the determination of olmesartan medoxomil in pharmaceutical dosage forms.

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