Rajkot

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF FIRST ORDER DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF AMILORIDE AND TORSEMIDE IN THEIR COMBINED PHARMACEUTICAL DOSAGE FORM

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About Authors:
Krutika J. Bhalodiya*, Nehal Ghelani, Darshan Madiya, Shital Faldu
Department of Quality Assurance
Smt. R. D. Gardi B. Pharmacy College, Rajkot
bhalodiyakruti1@gmail.com

Abstract
UV Spectrophotometric method has been developed for simultaneous estimation of Amiloride (AML) and Torsemide (TSM) in bulk drug and in their combined dosage form by first order derivative. This method utilizes methanol as a solvent and λmax of Amiloride and Torsemide selected for analysis was found to be 248 nm(at ZCP of TSM) and 308 nm (at ZCP of AML) respectively. Linearity was observed in the concentration range of 4-14μg/ml for AML (r2 = 0.999) and 4-20 μg/ml for TSM  (r2 = 0.998). The accuracy and precision were determined and found to comply with ICH guidelines. This method showed good reproducibility and recovery with % RSD in the desired range. The proposed methods can be successfully applied for the routine analysis of both the drugs. This method was simple, rapid, accurate, and sensitive.

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF FIRST ORDER DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF PARACETAMOL AND PROPYPHENAZONE IN THEIR COMBINED PHARMACEUTICAL DOSAGE FORM

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About Authors:
Mehul Kakdiya*, Avinash Nagapara, Darshan Madiya, Shital Faldu
Department of Quality Assurance,
Smt. R. D. Gardi B. Pharmacy College, Rajkot, Gujarat, India
*kakdiyamehul@gmail.com

Abstract
A simple, precise, accurate and reproducible spectrophotometric method has been developed for  simultaneous estimation of Paracetamol (PCM) and Propyphenazone (PP) by employing first order derivative zero crossing method in Methanol. The first order derivative absorption at 249 nm (zero cross point of Paracetamol) was used for quantification of Propyphenazone and 274 nm (zero cross point of Propyphenazone) for quantification of Paracetamol. The linearity was established over the concentration range of 1-12 µg/ml and 5-24 µg/ml for Paracetamol and Propyphenazone with correlation coefficient r2 0.999 and 0.996, respectively. The mean % recoveries were found to be in the range of 100.48-102.119% and 100.448-102.713 % for Paracetamol and Propyphenazone, respectively. The proposed method has been validated as per ICH guideline and successfully applied to the estimation of Paracetamol and Propyphenazone in their combined pharmaceutical dosage form.

Invitation for the post of Business Executives (Medical Representatives) @ DelCure LifeSciences

DelCure LifeSciences Ltd. (DLL) is a full scale pharmaceutical company with an aim to bring differentiated high quality products through international collaboration with innovator companies from the USA, Switzerland, and European countries. High quality products are assured from our manufacturing partner of high repute.
Vision:
“To become the most respected, uniquely positioned leading pharmaceutical company in the chosen areas or specialty verticals in India and abroad with distinct value based characteristics”.
Purpose, Culture and Value at DelCure LifeSciences:
At DelCure LifeSciences, we strongly believe in promoting the purpose of Happiness and creating the culture of Helpfulness for DLL family members and the society, with the learning from Mother Nature, promoting sustainability and augmenting life with growth. We firmly believe in value of Truthfulness.
The Visionary:
The company was envisioned by pharma veteran Mr. Prashant Kumar Pathak. An inspiring and visionary leader has approximately three decades of rich experience in pharmaceutical industry in Sales & Marketing, International Business, and Supply Chain Management & Operations. Mr. Pathak served as Chief Executive – Global Formulations with RPG Lifesciences and Senior Director – Sales & Marketing with Dr. Reddy’s Laboratories.

Post: Business Executives (Medical Representatives)

Q-ABSORBANCE RATIO SPECTROPHOTOMETRIC METHOD FOR THE SIMULTANEOUS ESTIMATION OF PARACETAMOL AND PROPYPHENAZONE IN THEIR COMBINED PHARMACEUTICAL DOSAGE FORM

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About Authors:
1Mehul Kakdiya*, 2Viral Kakdiya, 1Darshan Madiya
1Department of Quality Assurance,
Smt. R. D. Gardi B. Pharmacy College, Rajkot
2Pacific college of pharmacy, Udaipur, Rajasthan
*kakdiyamehul@gmail.com

Abstract
The present manuscript describes simple, sensitive, rapid, accurate, precise and economical Q-absorbance ratio method for the simultaneous determination of Paracetamol and Propyphenazone in their combined pharmaceutical dosage form. Absorbance ratio method uses the ratio of absorbance at two selected wavelengths, one which is an isoabsorptive point and other being the λ-max of one of the two components.  Paracetamol and Propyphenazone show an isoabsorptive point at 264 nm in methanol.The second wavelength used is 249 nm, which is the λ-max of Paracetamol in methanol. The linearity was obtained in the concentration range of 1-12 μg/ml for Paracetamol and 5-24 μg/ml for Propyphenazone. The concentrations of the drugs were determined by using ratio of absorbance at isoabsorptive point and at the λ-max of Paracetamol. The method was successfully applied to pharmaceutical dosage form because of no interference. The results of analysis have been validated by recovery studies.

Q-ABSORBANCE RATIO SPECTROPHOTOMETRIC METHOD FOR THE SIMULTANEOUS ESTIMATION OF AMLODIPINE BESYLATE AND CANDESARTAN CILEXETIL IN SYNTHETIC MIXTURE

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ABOUT AUTHORS:
Kotecha B*, Pambhar M, Zala G, Faldu S
Department of Quality assurance, Smt. R.D. Gardi B.Pharmacy College,
Nyara, Rajkot-360 110, Gujarat, India
kotecha_bijal29@yahoo.com

ABSTRACTS:
The present manuscript describe simple, sensitive, rapid, accurate, precise and economical q-absorbance method for the simultaneous determination of Amlodipine besylate and Candesartan cilexetil in synthetic mixture. Absorbance ratio method uses the ratio of absorbance at two selected wavelengths, one which is an Isoabsorptive point at 242 nm in Methanol. The second wavelength is used 255 nm, which is λmax of Candesartan cilexetil in Methanol. The linearity was obtained in the concentration range of 5-25 μg/mlof both drugs. The concentration of drugs was determined by using ratio of absorbance at isoabsorptive point and at the λ-max of Candesartan cilexetil. The method was successfully applied to pharmaceutical dosage form because of no interference. The result of analysis has been validated by recovery studies.

CHALCONE: A VERSATILE CHEMICAL ENTITY

ABOUT AUTHORS:
Sarthak B. Dave*, Dr. Dipen K. Sureja.
Department of Pharmaceutical Chemistry,
Shree H. N. Shukla Institute of Pharmaceutical Education & Research,
Rajkot, Gujarat, India
*davesarthak@ymail.com

ABSTRACT:
Chalcones are 1, 3-diphenyl-2-propene-1-one, consist of two aromatic rings linked by a three carbon a, ß-unsaturated carbonyl system. Mainly chalcone are synthesized by Claisen-schmidt condensation reaction (Cross-aldol reaction). Chalcones are well known intermediates for synthesizing various heterocyclic compounds. Chalcones, precursors of open chain flavonoids and isoflavonoids present in edible plants, and their derivatives have attracted increasing attention due to numerous potential pharmacological applications. They have displayed a broad spectrum of pharmacological activities. Changes in their structure have offered a high degree of diversity that has proven useful for the development of new medicinal agents having improved potency and lesser toxicity. The present review highlights the recently synthesized Chalcones and their derivatives possessing important pharmacological activities.

CAPSULE FORMATION: FROM CONVENTIONAL TO ADVANCED

ABOUT AUTHORS:
Vivek P. Chavda*, Maunit B. Mehta, Hamir B. Vala, Nirav A. Pandya
Department of Pharmaceutics, B.K. Mody Government Pharmacy College,
Rajkot – 360003, Gujarat (India)
*vivek7chavda@gmail.com

INTRODUCTION
Early 19th century, Mathes developed the first capsule dosage form from gelatin. We are familiar with capsule since a century.[1] It has been transformed in a different way to serve the society and to provide the additional benefits rather than the conventional gelatin capsule. A capsule is a shell or a container prepared from gelatin containing one or more medicinal and/or inert substances.[2] The gelatin capsule shell may be soft or hard depending on their formulations. Capsules are solid dosage forms in which the medication contained within gelatin shells. The medication may be a powder, a liquid or a semisolid mass. Capsules are intended to be swallowed whole by the patient. In instances where patients (especially children) are unable to swallow capsules, the contents of the capsule can be removed and added (e.g., sprinkled) on soft food immediately before ingestion. In this case, capsules are used as a vehicle to deliver premeasured medicinal powder. Capsule dosage forms occupy more than 10% of the total dosage forms on the market.[3] Soft gelatin capsule are available in oblong, spherical, elliptical and other shapes. They are also available in sizes to contain from 0.1 to 30 ml of volume. The various size of hard gelatin capsule is given in table 1.

PHOTOSTABILITY TESTING

ABOUT AUTHOR:
Mr. Vivek P. Chavda, Dr. Moinuddin M. Soniwala
Department of Pharmaceutics, B.K. Mody Government Pharmacy College,
Rajkot – 360003, Gujarat (India)
vivek7chavda@gmail.com

INTRODUCTION1,2
In recent years, many important initiatives have been undertaken by regulatory authorities and industry associations to promote international harmonization of regulatory requirements. International Conference on the Harmonization of Technical Requirements for the Registration of Pharmaceuticals for Human Use (ICH) was organized in April 1990 and has as its sole and primary purpose the creation of international standards for the purpose of pharmaceutical research. This process was initiated in order to harmonize the submission requirements for new pharmaceuticals in the three main regions of Europe, the United States, and Japan and to avoid duplication, inefficiencies and delays.

The six cosponsors of ICH were

  1. European Commission,
  2. European Federation of Pharmaceutical Industry Association (EFPIA),
  3. Japanese Ministry of Health (MHW),
  4. Japanese Pharmaceutical Manufacturers Association (JPMA),
  5. Food and Drug Association (FDA), and the Pharmaceutical Research
  6. Manufacturers of America (PhRMA)

DEVELOPMENT AND VALIDATION OF REVERSE PHASE LIQUID CHROMATOGRAPHIC METHOD FOR SIMULTANEOUS ESTIMATION OF TAPENTADOL HYDROCHLORIDE AND PARACETAMOL IN BULK DRUG AND IN PHARMACEUTICAL DOSAGE FORM

ABOUT AUTHORS:
Chandani Joshi*1, Chetana Ribadiya2, Nimish Talaviya3, Dainik Manavar4, Rakesh Radadia5, Dr. Shital Faldu6
1,3,4M.Pharm, Smt. R. D. Gardi B. Pharmacy College, Rajkot
2M.Pharm, Smt. R. B. Patel Mahila Pharmacy College, Atkot
5M.Pharm, Mts. V. B. Manvar Pharmacy college, Rajkot.
6M.Pharm, Ph. D., Principal, Smt. R. D. Gardi B. Pharmacy College, Rajkot
*chandani11aug@gmail.com

ABSTRACT
A simple, rapid, accurate, precise and reproducible reverse phase high performance liquid chromatographic method has been developed for the estimation of Tapentadol hydrochloride and paracetamol was determined using reversed phase liquid chromatography method using ODS Hypersil C18 column (250 mm × 4.6 mm id, 5μm as a stationary Phase and Methanol : Phosphate Buffer (pH 6.5) (50:50, v/v) as a mobile phase pumped at a flow rate of 1.5 ml/min. Quantification was achieved with ultraviolet detection at 225 nm over concentration ranges of 130-390 μg/ml for Paracetamol and 20-60 μg/ml for Tapentadol hydrochloride with mean accuracy 100.12 ± 0.3329 and 98.97±0.6345 %, for paracetamol and Taprntadol hydrochloride respectively. The method was successively applied to  dosage forms as no chromatographic interferences from the tablet excipients were observed. The method retained its accuracy and precision when the standard addition technique was applied.

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