• PharmaTutor
    1 July 2013

    THERMAL ANALYSIS: A USEFUL TOOL IN PREFORMULATION STUDY

    About Author:
    Vivek P. Chavda
    Department of Pharmaceutics,
    B.K. Mody Government Pharmacy College,
    Rajkot – 360003, Gujarat (India)
    vivek7chavda@gmail.com

    Introduction
    Thermal method of analysis are group of techniques in which changes in physical and /or chemical properties of a substance are measured as a function of temperature, while substance is subjected to controlled temperature programmes.[1]Thermal analysis and calorimetric methods have demonstrated a wide array of applications in the Preformulation, and formulation development. These techniques are critical in physical–chemical screening of early discovery leads, during salt form screening, and in the characterization of polymorphs to determine the thermodynamic relationships between the various crystal forms.[2]

  • 30 June 2013
    Shoolini University offers admission for B.Pharmacy, M. Pharmacy (Pharmaceutics, Pharm. Chemistry, Pharmacology, Pharmacognosy, Quality assurance, Biotechnology), B. Pharm MBA (Integrated), and PhD programs

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  • 19 June 2013
    Career for Area Sales Manager in Leading for Pharma Company - Nextus Solutions

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  • 31 May 2013
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  • 26 May 2013
    Opportunity to get Training for Medico-Medical Writing in Tulip Medcom

    Medical writing is part and parcel of drug development process. Medicomarketing communication or healthcare communication has evolved as a profession over a decade. More and more pharmaceutical industries are outsourcing their work to medicomarketing communication or healthcare communication companies/freelance medical writers.

  • 27 February 2013
    Walk in interview for the Post of Pharmacist in Western Railway- 3 Posts

    Western Railway Rajkot Division has issued notification and invites qualified candidates for walk in interview for total 10 posts of full time Para- Medical staff in Medical department purely on contract base. Interested and eligible candidates may walk for interview along with necessary documents. The details of the posts such as educational qualification, application format, posting place and other details are given below.

  • 27 January 2013
    Sales Vacancies as Medical Representative, Area manager, Marketing Executive in ASTRUM GENETICA

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  • 20 November 2012
    DETERMINATION OF PKA OF ACTIVE PHARMACEUTICAL INGREDIENT BY SPECTROMETRY

    About Authors:
    Kalpesh Ashara
    Registered Pharmacist S.K.R.I.Medicines Centre, Rajkot, Gujarat, India,
    M.Pharm Semester-I Student of B.K.Mody Govt.Pharmacy College Rajkot,
    Department of Pharmaceutics GTU, Gujarat, India.
    kalpeshashara@yahoo.com, kalpeshshr5@gmail.com*

    Abstract:
    Spectrophotometry is an attractive method for PKa determination in very diluted aqueous solution about 10-5 to 10-6M provided that the compound possesses PH dependent light absorption due to the presence of a chromospheres in proximity to the ionization centers. Traditionally 6 to 8 aliquot solutions of samples in identical concentrations but with different PH values are prepared & their absorption spectra are registered at single wavelength. This series of solutions can be generated by either preparing the sample in buffer solutions of known PH or titrating the sample solution e.g. alkalimetry. Then half the absorbance of maximum plotted on graph & interpolated on x-axis that will give value of PH is Pka  & negative Antilog of that value at base 10 give value of ka i.e. Dissociation Constant (Pka=-logka). This exercise is carrying out in below assignment.

  • 5 November 2012
    PREPARATION & EVALUATION OF MICROSPHERES OF DICLOFENAC SODIUM BY SURFACE ACTIVE AGENT SLS

    About Authors:
    *Kalpesh Ashara, Jignesh Solanki
    B.K.Mody Govt.Pharmacy College Rajkot,
    Department of Pharmaceutics,GTU, Gujarat, India.
    *kalpeshshr5@gmail.com

    Abstract:
    Microspheres are solid spherical particles containing a dispersed drug in organic solution fall in a range of 1-1000mm. Microspheres or micro particles are monolithinic device refer to a rate controlling matrix throughout the drug is dissolved or dispersed, while microcapsules are device which consists of cell-like dosage forms with the drug contain within the rate controlling membrane. Microspheres are prepared by several methods. Here Microspheres are prepared using a surface active agent SLS. Then Evaluation of Microspheres is carried out by means of several parameters. Then concluded that the diclofenac: polymer ratio of 1:2 & organic solvent (MeOH: DCM) ratio of 1:4 was found to be optimum for spherical shape of microspheres as well as Practical Yield.

  • 24 September 2012
    FORMULATION AND EVALUATION OF OCULAR INSERT OF ACYCLOVIR

    About Authors:
    Mistry G. S*, Patel S. D, Tank H. M
    Matushree V. B. Manvar College of Pharmacy
    Dumiyani, Rajkot.
    *Gaurav_mistry123@yahoo.com

    ABSTRACT
    Acyclovir is an Anti-viral drug, widely used in the treatment of Ocular herpes simplex. Ophthalmic insert of acyclovir formulated using Methyl cellulose (MC A4CP), polyvinylpyrrolidone (PVP K30) and polyvinyl alcohol as polymers and glycerin use as plasticizer by solvent casting method with aim of increasing the contact time, achieving sustained release drug. The prepared ophthalmic insert were evaluated for uniformity of thickness, weight uniformity, drug content, % moisture absorption, % moisture loss, folding endurance and surface pH. In vitro drug release of formulated batches was performed using Modified Franz Diffusion cell. A 32 full factorial design was applied to systematically optimize the ocular insert. FTIR spectroscopy was performed to study the drug interaction effect in formulation using KBr disc method. On the basis of all physicochemical parameters and in vitro drug release studies, and overall Desirability, the formulation (F8) was found to vary significantly depending on the type of polymers used and their combinations and it was selected for sterility, stability, ocular irritancy study. The result of invitro diffusion study of formulation exhibited non-fickian in nature. From stability studies inserts were remained stable both physically and chemically. The formulation was found to be practically nonirritant in ocular irritation studies using hen's egg chorioallantoic membrane.

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