• 5 November 2012

    PREPARATION & EVALUATION OF MICROSPHERES OF DICLOFENAC SODIUM BY SURFACE ACTIVE AGENT SLS

    About Authors:
    *Kalpesh Ashara, Jignesh Solanki
    B.K.Mody Govt.Pharmacy College Rajkot,
    Department of Pharmaceutics,GTU, Gujarat, India.
    *kalpeshshr5@gmail.com

    Abstract:
    Microspheres are solid spherical particles containing a dispersed drug in organic solution fall in a range of 1-1000mm. Microspheres or micro particles are monolithinic device refer to a rate controlling matrix throughout the drug is dissolved or dispersed, while microcapsules are device which consists of cell-like dosage forms with the drug contain within the rate controlling membrane. Microspheres are prepared by several methods. Here Microspheres are prepared using a surface active agent SLS. Then Evaluation of Microspheres is carried out by means of several parameters. Then concluded that the diclofenac: polymer ratio of 1:2 & organic solvent (MeOH: DCM) ratio of 1:4 was found to be optimum for spherical shape of microspheres as well as Practical Yield.

  • 24 September 2012
    FORMULATION AND EVALUATION OF OCULAR INSERT OF ACYCLOVIR

    About Authors:
    Mistry G. S*, Patel S. D, Tank H. M
    Matushree V. B. Manvar College of Pharmacy
    Dumiyani, Rajkot.
    *Gaurav_mistry123@yahoo.com

    ABSTRACT
    Acyclovir is an Anti-viral drug, widely used in the treatment of Ocular herpes simplex. Ophthalmic insert of acyclovir formulated using Methyl cellulose (MC A4CP), polyvinylpyrrolidone (PVP K30) and polyvinyl alcohol as polymers and glycerin use as plasticizer by solvent casting method with aim of increasing the contact time, achieving sustained release drug. The prepared ophthalmic insert were evaluated for uniformity of thickness, weight uniformity, drug content, % moisture absorption, % moisture loss, folding endurance and surface pH. In vitro drug release of formulated batches was performed using Modified Franz Diffusion cell. A 32 full factorial design was applied to systematically optimize the ocular insert. FTIR spectroscopy was performed to study the drug interaction effect in formulation using KBr disc method. On the basis of all physicochemical parameters and in vitro drug release studies, and overall Desirability, the formulation (F8) was found to vary significantly depending on the type of polymers used and their combinations and it was selected for sterility, stability, ocular irritancy study. The result of invitro diffusion study of formulation exhibited non-fickian in nature. From stability studies inserts were remained stable both physically and chemically. The formulation was found to be practically nonirritant in ocular irritation studies using hen's egg chorioallantoic membrane.

  • 21 September 2012
    BIOSENSOR - Micro electrochemical device

    About Authors:
    Vedant M. Pandya
    Department of biotechnology, shree M & N Virani science college,
    Rajkot, India-360005
    vedantpandya007@gmail.com

    ABSTRACT
    A biosensor is a device for the detection of an analyte that combines a biological component with physicochemical detector components. An integrated device consisting of a biological recognition element & a transducer capable of detecting the biological reaction & converting it into a signal which can be processed. Ideally, the sensor shod be self-contained, so that it is not necessary to add reagents to the sample matrix to obtain the desired response. There are a number of analytes which are measured in biological media: pH, partial pressure of carbon dioxide, partial pressure of oxygen & the ionic concentration of sodium, potassium, calcium & chloride. Biosensors are typically classified by the type of recognition element or transduction element employed. Sensors might be described as a catalytic biosensor if it is recognition element comprised an enzyme or series of enzymes, a living tissue slice, or whole cells derived from microorganisms such as bacteria, fungi, or yeast. The sensor might be described as a bioaffinity sensor if the basis of operation were a biospecific complex formation. Accordingly, the reaction of an antibody with an antigen or hapten, or the reaction of an ageist or antagonist with a receptor, could be employed. In the former case, the sensor might be called an immunosensor. Since, enzyme-based sensor measure the rate of the enzyme-catalyzed reaction as the basis for their response, any physical measurement which yield a quantity related to this rate can be used for detection. The enzyme may be immobilized on the end of an optical fiber, & the spectroscopic properties related to the disappearance of the reactants or appearance of products of the reaction can be measured. Since biochemical reaction can be either endothermic or exothermic. Miniaturized thermistor based calorimeter called thermistos, have been developed & widely applied, especially for bioprocess monitoring.

  • 22 August 2012
    FORMULATION AND EVALUATION OF GASTRORETENTIVE FLOATING DRUG DELIVERY SYSTEM OF PIOGLITAZONE HYDROCHLORIDE

    About Authors:
    *Thoriya J. G, Patel S. D, Tank H. M
    Matushree V. B. Manvar College of Pharmacy- Dumiyani,
    Rajkot
    *thoriya.jignesh@gmail.com

    ABSTRACT
    Pioglitazone HCl is used for the management of type-2 diabetes. It is an absorption window limited drug, whose solubility decreases with increase in the pH and has a short half life of 3-7 h. Here an attempt is made to developed the floating matrix tablets, which design in way that after oral administration the GI resistant time is  prolonged and thus to give sustained action with increase in the bioavailability of the drug. Pioglitazone HCl showed maximum absorption at wavelength 269 nm in 0.1N HCl. various formulations were developed by using release rate controlling and gel forming polymers like HPMC, and Carbopol-934 in single and combinations by direct compression method with the incorporation of sodium bicarbonate as gas generating agent. The prepared tablets were characteristics by drug content, floating property, swelling and in vitro dissolution test using USP dissolution test apparatus Type – II (paddle method) in dissolution medium of 0.1 N HCl. The in vitro dissolution results of all tablets were computed by using dissolution software. The prepared tablets were found to be good hardness, diameter, weight variation, thickness, friability drug content, floating property and in vitro drug release. Drug-polymer compatibility studies by FTIR gave conformation about drug purity and showed no interaction between drug and selected polymers. All the formulations had floating lag time below 3 minutes and constantly floated on dissolution medium for more than 12 h. Swelling studies indicated significant water uptake and contributed in drug release. From among all the developed formulations, as F7 prolonged the drug release (95.45 %) for longer period of time (12 hrs.); they were selected as best formulations. The best formulations were found to be stable during stability studies for two months. Thus, selected formulations satisfied floating time, swelling index and in vitro drug release profile requirements for a floating drug delivery system.Tablets of Pioglitazone HCl prepared with HPMC K4M, HPMC K100M and Carbopol 934P were found to be acceptable floating property, water uptake and in vitro drug release.

  • 21 August 2012
    BIOLOGICAL DECOLORIZATION OF TEXTILE DYE USING MICRO ALGAE

    About Authors:
    Vedant Pandya
    M.Sc. Biotechnology,
    Department  Of  Biotechnology,
    Shree M.N.Virani Science College, Rajkot
    vedantpandya007@gmail.com

    Abstract :
    The potential of Cosmarium species, belonging to green Micro algae, was investigated as a viable biomaterial for biological treatment of triphenylmethane dye, Malachite Green (MG).  This can be used for the bioremediation of dye effluents. The results obtained from the batch experiments revealed the ability of algal species in removing dye.  The effects of operational parameters (temperature, pH, dye concentration and algal  concentration) on decolorization were examined.  The stability and efficiency of the algae in long-term repetitive operations were also examined. Michaelis–Menten kinetics was used to describe the apparent correlation between the decolorization rate and the dye concentration.

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  • 24 July 2012
    Juggat Pharma invites for various positions in all major cities of Gujarat, Rajasthan & Madhya Pradesh

    Juggat Pharma, Pharmaceutical Division of Jagdale Industries Limited is one of the fastest growing and high performing pharmaceutical marketing company with a global presence based at Bangalore, Karnataka. We provide an ideal environment for highly qualified and committed professionals to pursue their career Under the expansion plan, we are looking for 'Marketing Professionals' in Gujarat/Rajasthan/Madhya Pradesh.

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  • 27 June 2012
    Vacancy as Pharmacist in Sterling Hospitals | Multiplace Vacancies

    Sterling Hospitals, established in 2001 and owned and managed by Sterling Addlife India Ltd., is the largest chain of Corporate Hospitals in Gujarat.

  • 30 May 2012
    A Client of Aple Pharma require Medical Representative & Area Manager | Multiplace Vacancies

    A leading Pharmaceutical Company requires Medical Representative at all the major HQ's in India.

    Post: Medical Representative & Area manager

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  • 25 April 2012
    Openings for Posts of Area Manager, Medical Representative in Alteza Healthcare

    Alteza healthcare Pvt. Ltd. is newly established company. The company is heaving it's headquarter at Ahmedabad. Currently the company is in process of hiring of every level of employees. Currently we are hiring for ahmedabad district, rajkot district, surendranagar district, bhavnagar district.

    Post: Area Manager, Medical Representative

  • 29 March 2012
    Require Medical Representative & Area Sales Manager at Neo Cardiab Care

    The company is dedicated to advancing the practice of medicine by reducing risk wherever possible and contributing to successful outcomes for every patient. Headquartered in India have major focus areas of human health that include: cardiac management, cardiology, diabetolology and neuropsychiatry.

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