Maharashtra

About Authors:
Birajdar Shivprasad M.*, Mule Madhav¹
*Department of Quality Assurance, Maharashtra College of Pharmacy, Nilanga.
¹School of Pharmacy, Swami Ramanand Teerth Marathwada University
Vishnupuri, Nanded-431606, Maharashtra, India,
*birajdar100@gmail.com

Abstract
Preservatives have been used and known to mankind since a very long time. These are used in cosmetics to increase the shelf life of product so that aroma, taste and the cosmetics itself can be stored for a longer period of time. Also cosmetics degradation is prevented by them. Preservatives, whether natural or artificial, work as in three different ways: Antimicrobial, Antioxidants and Act on enzymes. In antimicrobial, the growth of microbes like bacteria and fungi is inhibited. In antioxidants the process of oxidation is either delayed or stopped. And the one that acts on enzymes stops the ripening or aging of cosmetics product. Preservation is important part in many industries, such as the cosmetic and pharmaceutical industries, as the shelf life of many cosmetic and pharmaceutical products is important. The present review is an extensive compilation of various preservatives obtained from plant, synthetic and microbial source.The safety of preservatives is always coming into question. Since these are all biologically active products, they all have potential for being toxic, or irritating, or sensitizing.

NEXTUS SOLUTIONS is a professionally managed organization engaged in offering highly acclaimed consulting, Training and Placement.

Merck Limited (formerly E. Merck Limited) was set up in India as the first Merck subsidiary in Asia in 1967. The Company operates both its Pharmaceuticals and Chemicals businesses in the country.

About Authors:
AMOL D.GHOLAP^*1, DATTATRAY TUPE^2
1Department of Pharmaceutics, Vamanrao Ithape D. Pharmacy College,
Velhale, Tal- Sangamner, Dist- Ahmednagar, MS-422605, India.
²Department of Regulatory Affairs, Lupin Limited,
Kalina, Santakruz (E), Mumbai, MS, India-400098.
*amolgholap16@yahoo.com

Abstract
The several evolutions in the field of medicine develop different cellular mechanisms for striking along with entering the target cells with efficiency. The utilization of recombinenet adenovirus as carriers for cDNA induces dose along with therapy limiting of defense mechanisms. Artificial viral envelopes (AVE) are lipid vesicles which mimic with fusogenic envelop of retrovirus to utilize as target selectivity along with efficiency of delivery of viruses. The major component of AVE includes phosphatidylcholine, phosphatidyiserine along with sphingomyelins. The negative charge is present on AVE’s help them for targeting the moieties such as viral binding proteins. The artificial viral envelopes show potential applications in plasmid delivery.

About Authors:
AMOL D.GHOLAP^*1, DATTATRAY TUPE^2
1 Department of Pharmaceutics, Vamanrao Ithape D. Pharmacy College, Velhale, Tal- Sangamner, Dist- Ahmednagar, MS-422605, India.
² Department of Regulatory Affairs, Lupin Limited, Kalina,
Santakruz (E), Mumbai, MS, India-400098.
*amolgholap16@yahoo.com

Abstracts
There are several newer lipid based systems are evoked and utilized now a days as dryg delivery systems like liposomes, transferosomes, ethosomes etc which provides effective solutions for problem regarding insolubility, instability, rapid degradation along with has wide application in the specialized area consisting protein delivery, targeting to the brain, and tumor targeting. This lipid based systems also utilized in for gene delivery with efficient performance while in this field the colloidosomes evoked as potential tool based on the vascular drug delivery system. There are several applications of vascular systems are present including reduction in the cost of therapy via improved bioavailability of medication generally in the case of poorly soluble drugs. The colloidosomes have several beneficial advantages like greater encapsulation efficiency with wide control on the size along with permeability and compatibility. The colloidosomes also have effective mechanical strength.

The Tata Institute of Fundamental Research was conceived and founded by the distinguished Indian Scientist Dr. Homi Bhabha in June 1945 with the active support of the Sir Dorabji Tata Trust and the Government of Bombay Presidency.  In 1962, the Institute shifted to its present picturesque campus at Colaba on the shores of the Arabian Sea.

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