Tamil Nadu

Antioxidant Activity of Flowers and Leaves of Tabernaemontana Divaricata Linn.

About Author: C. Stalin*, S. Kamalasivam, E. Hariharan,
Pallavan College of Pharmacy,
Kancheepuram, Tamilnadu.

Tabernaemontana divaricata a common garden plant in tropical countries has been used as a traditional medicine. However, no recent review articles of T. divaricata, particularly discussing its pharmacological properties, are available. In present study, the antioxidant activity of ethanolic extract of flowers and leaves of Tabernaemontana divaricata linn were evaluated . Free radicals have been regarded as a fundamental cause of different kinds of diseases. They cause biochemical damage in cells and tissues, which result in several diseases such as arteriosclerosis, ischemia-reperfusion injury, liver disease, diabetes mellitus, inflammation, renal failure, aging, cancer, etc. Compounds that can scavenge free radicals are thus effective in ameliorating the progress of these related diseases. T.divaricata L. known locally as ‘Nandiyavattom’ belonging to the family, Apocynaceae a common plant in India, profoundly used in Ayurvedic medicine as  Anthelmintic, Anti-inflammatory, Anodyne, Diuretic property.1 The objective of the present study was designed to investigate the antioxidant efficacy of ethanolic extract of leaves and flower of Tabernaemontana divaricata (TALE & TLFE). Invitro antioxidant activity such as Reducing power ability ,  NBT reduction assay, Deoxyribose degradation assay was performed and was concluded that the ethanolic extract of leaves and flowers of Tabernaemontana divaricata showed significant antioxidant activity.

Transdermal Drug Delivery System: An Overview

About Authors:Niroj Shrestha*, D. Nagasamy Venkatesh**, Jeevan Sharma
J. S. S. College of Pharmacy, Ooty, Tamilnadu, India
*Final Year B.Pharmacy Student.
**For correspondence:
Department of Pharmaceutics
J. S. S. College of Pharmacy,
(A constituent college of JSS University, Mysore)
Ooty – 643 001.
Tamil Nadu, India.

Reference ID: PHARMATUTOR-ART-1068

Transdermal drug delivery system (TDDS) has emerged as a potential novel drug delivery system in the last 30 years to improve the therapeutic efficacy and safety, maintain steady state plasma level of drugs and overcome significant drawbacks of the conventional oral dosage forms and parenteral preparations. TDDS is ideally suited for diseases that demand chronic treatment with frequent dosing. This review deals with a brief insight on the formulation aspects, the physical and chemical enhancers being explored to enhance the transdermal delivery of drugs across the stratum corneum, the evaluation parameters (physicochemical, in vitro, in vivo studies) and therapeutic applications of TDDS.