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Capryloyl glycine - Multifunctional active for Cosmetics

 

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Capryloyl glycine - Multifunctional active for Cosmetics

Vinay KumarVinay Kumar Singh. 
Head-Formulation
Kumar Organic Products Research Centre Pvt. Ltd.,
Bengaluru
Email : formulation_krc@kopresearchcentre.net

Capryloyl Glycine (Koproyl glycine) is synthesized through a chemical process that combines glycine, an amino acid, with caprylic acid, a fatty acid. This reaction results in the formation of Capryloyl Glycine, which is then further processed and purified for use in cosmetics. Capryloyl Glycine serves multiple purposes in cosmetics, primarily as a gentle surfactant, emollient, and skin- conditioning agent. It can restrict the growth of bacteria. Capryloyl Glycine also controls excessive secretion of sebum, making it conducive to prevent and treat acne. It helps carry the active ingredient and reduce wrinkles. It also helps in maintaining the skin& moisture balance, preventing excess oiliness without causing dryness. Capryloyl Glycine typically appears as a clear to slightly yellowish liquid. This versatile ingredient is often found in products like cleansers, moisturizers, and anti-acne formulations, contributing to their effectiveness while being gentle on the skin.

The Global Capryloyl Glycine market is anticipated to rise at a considerable rate during the forecast period, between 2024 and 2032. In 2023, the market is growing at a steady rate and with the rising adoption of strategies by key players, the market is expected to rise over the projected horizon.

Capryloyl glycine is a lipid amino acid. It is obtained by acylation of glycine to the octanoyl fatty chain. Glycine is the simplest and only one-amino acid that does not have a chiral carbon. It is also used for the biosynthesis of a plurality of important physiological substances in the organism.
It is one of the main components of dermal structural proteins, therefore, it plays an extremely important role in the skin, especially in the metabolism of skin cells and skin moisturising. Caprylic acid and glycine are both widely found in plants. The combination is beneficial in skin moisture retention and collagen synthesis. It can regulate alkaline-acidity, balance the skin’s environment, prevent excessive keratinisation and inhibit harmful microbes.
Use of CAPRYLOYL GLYCINE 
Capryloyl Glycine has multifunctional properties that greatly benefit the personal care industry.
•    Skin care: It serves as an effective ingredient in facial cleansers and toners, helping to control excess oil and minimize breakouts. Additionally, it contributes to maintaining skin's moisture balance without causing dryness or irritation. Its gentle nature makes it suitable for sensitive skin types, promoting a clear and healthy complexion
•    Hair care: It is utilized in shampoos and scalp treatments. It aids in cleansing the scalp, removing excess oil and buildup, and promoting a balanced and refreshed scalp environment. This can help in managing greasy hair and supporting overall hair health and cleanliness


Function of Capryloyl glycinein cosmetic products are as below.
ANTI-SEBORRHEIC
Prevents seborrhea and / or seborrheic dermatitis or relieves their symptoms; and / or acts against dandruff
ANTI-SEBUM
Inhibits sebum production
ANTIMICROBIAL
Helps control the growth of micro-organisms (eg bacteria and fungi)
DEODORANT
Reduces or masks unpleasant body odours
HAIR CONDITIONING
Leaves the hair easy to comb, supple, soft and shiny and / or imparts volume
SURFACTANT - CLEANSING
Surface-active agent to clean skin, hair and / or teeth
Capryloyl glycine works by helping to improve the skin’s barrier function, which can lead to improved hydration and a reduction in the appearance of fine lines and wrinkles. It also has antimicrobial properties, which makes it effective at reducing the appearance of acne-prone skin.
In addition to its benefits for the skin, capryloyl glycine has also been shown to have anti-inflammatory properties, which can help to reduce redness and irritation.

Several studies have been conducted on the effectiveness of capryloyl glycine in skincare. A study published in the Journal of Drugs in Dermatology found that a 2% capryloyl glycine gel was effective at improving the appearance of acne-prone skin. Another study, published in the International Journal of Cosmetic Science, found that a 5% capryloyl glycine cream was effective at reducing the appearance of fine lines and wrinkles.
Capryloyl glycine can be found in a variety of personal care products, including cleansers, moisturizers, serums, and acne treatments. It is often used in combination with other ingredients, such as salicylic acid and benzoyl peroxide, to enhance its effectiveness.


Capryloyl Glycine is generally considered safe for use in personal care products. It has a low potential for skin irritation and is well-tolerated by most individuals. However, as with any cosmetic ingredient, allergic reactions are possible, so it is advisable to perform a patch test in case of sensitive skin or when using a new product containing Capryloyl Glycine.

Capryloyl glycine has a good affinity for the skin; it can efficiently transport the active ingredients in cosmetics, thereby improving the use effect of functional products; with its suppression of excess sebum secretion, it has shown good oil control and strong suppression of Staphylococcus aureus and Propionibacterium acnes.