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  • ANTIDEPRESSANT ACTIVITY ON LEAVES OF POLYGONUM GLABRUM WILLD IN EXPERIMENTAL ANIMAL

    About Authors:
    Deepak singh1*, Arpit Dixit2, Amir khan3, Vikas singh4, Abhishek sachan4
    1*Department of Clinical Research, Jamia Hamdard, Hamdard nagar, New Delhi-110062
    2Business executive at Merck Pvt.ltd, Ghaziabad, India
    3Business executive at Cipla Pvt.ltd, Lucknow, India
    4Shri RLT Institute of Pharmaceutical Science & Technology, Etawah(UP), India
    *deep_singh4u21@rediffmail.com

    ABSTRACT:
    The present investigations, which were primarily conducted with the aim of investigating some neuropharmacological activity of Polygonum glabrum (PG), i.e. PG has got anxiolytic activity when tested against open field exploratory behavior, where as elevated plus maze did not show any positive results. The action produced by PG was more than that of diazepam in open field exploratory behaviour. Observations confirms that PG possesses significant antidepressant activity. The observed antidepressant activity of PG was qualitatively comparable to that induced by Imipramine. Pentobarbitone induced hypnosis in mice was significant potentiated by PG.PG at 100 and 200mg/kg, reduced locomotor activity in rats.The PG seems to be little or no motor incoordination effect in mice when tested against rota-rod test.PG had significant analgesic activity which is both centrally and peripherally mediated, when tested against various analgesic models in rodents.The investigations indicates that PG has significant analgesic, anti-inflammatory, antidepressant and anxiolytic actions, some of these actions, including antidepressant and anxiolytic can be rationalized on the basis of the neurochemical data emanating from this study . The present study indicate that PG can be clinically useful not only in inflammation, pain and fever, and worm infestation but also in depression and anxiety. Clinical studies are required to confirm the above mentioned activities.

  • Career for M.Pharm to work in research project at National Institute of Nutrition

    National Institute of Nutrition (NIN) was founded by Sir Robert McCarrison in the year 1918 as ‘Beri-Beri’ Enquiry Unit in a single room laboratory at the Pasteur Institute, Coonoor, Tamil Nadu. Within a short span of seven years, this unit blossomed into a "Deficiency Disease Enquiry" and later in 1928, emerged as full-fledged "Nutrition Research Laboratories" (NRL) with Dr. McCarrison as its first Director. It was shifted to Hyderabad in 1958.

    Eligible candidates are invited to apply for the following posts on the ad hoc research project entitled “Development of New Bio-maker for Quantification of Acetylcholinesterase (ache) Enzyme Activity Organophosphate Carbamates and Nerve Agent in Biological and Ambient Matrices”. The Project is funded by DHR and executing agency is NIN.

    Post : Senior Project Research Fellow

  • Job for Research Associate at ICTM

    The Institute of Chemical Technology (ICT) Mumbai was established as the Department of Chemical Technology on 1st October, 1933 by the University of Mumbai, through active support of industries and philanthropists. The Institute was most popularly known as UDCT, Mumbai. Research has been an integral part of ICT since its inception and it has created over 500 first generation entrepreneurs.

    Post : Research Associate

  • Career for Junior Research Fellow at South Asian University - B.Pharm, Integrated BS-MS/ MSc

    Applications are invited for the post of ONE Junior Research Fellow (JRF) in a CSIR-funded project entitled “Investigating the role of exogenous ATP in cancer metastasis” under the supervision of Dr. Ravi Shankar Akundi, Faculty of Life Sciences and Biotechnology, South Asian University, New Delhi. Fellowship is as per CSIR rules.

  • Recruitment for M.Pharm, M.Sc in Research Project at IHBT

    Govt. of Himachal Pradesh took up initiative in early seventies to set up a CSIR lab to make prudential use of the natural resources of the region. After several levels of discussions a formal request was made by then Chief Minister of HP to Vice President, CSIR in 1982 for initiating the matter, and giving final shape to the proposal. The dream of HP government finally came true in 1983 when the foundation stone of this National lab was laid as CSIR Complex Palampur by Prof. Nurul Hasan, former Vice President of CSIR, with then Chief Minister of HP chairing the function.

  • Career for Master Degree in Life Sciences as Research Scientist at RMRIMS

    Applications on plain paper for Walk-in-Interview are invited from suitable Indian Nationals for appointment for the following purely temporary posts (on contractual basis) respectively under mentioned project titled for a period of one year or till the end of project, whichever is earlier at RMRIMS (ICMR), Agmkuan, Patna – 800 007 (Bihar).

  • Applications are invited for Government Innovation Fellowship under CIC-B | salary 50,000/ month and grant of Rs. 5 lakhs

    Applications are invited for two positions of Post-Doctoral Innovation fellows (purely temporary basis) under Cluster Innovation Centre in Biotechnology (CIC-B) at Panjab University, Chandigarh. The CIC-B is sponsored by Biotechnology Industry Research Assistance Council (BIRAC), Govt. of India

    Post: Post- Doctoral Fellowship

  • Application are invited for Research Associate in PGIMER

    The PGIMER owes its inception to the vision of late Sardar Partap Singh Kairon, the then Chief Minister of Punjab and the distinguished medical educationists of the then combined state of Punjab, supported by the first Prime Minister of India Pt. Jawahar Lal Nehru who considered the institutions of scientific knowledge as temples of learning and the places of pilgrimage. The institute started in 1962 and Pt Jawahar Lal Nehru inaugurated the hospital now named “Nehru Hospital” on 7th July 1963. The Institute was originally under the Government of undivided Punjab. After the reorganization of the state, the administrative control of the institute passed on to the Union Territory of Chandigarh in November 1966. The Institute became an autonomous body under the Act of Parliament in 1967 functioning under the Ministry of Health and Family Welfare, Government of India.

    Post: Research Associate

  • Walk in Interview for Research Associate at IHBT

    Govt. of Himachal Pradesh took up initiative in early seventies to set up a CSIR lab to make prudential use of the natural resources of the region. After several levels of discussions a formal request was made by then Chief Minister of HP to Vice President, CSIR in 1982 for initiating the matter, and giving final shape to the proposal. The dream of HP government finally came true in 1983 when the foundation stone of this National lab was laid as CSIR Complex Palampur by Prof. Nurul Hasan, former Vice President of CSIR, with then Chief Minister of HP chairing the function.

  • Job for M.Pharm, M.S Pharm as Junior Research Fellow at Birla Institute of Technology & Science

    The Birla Institute of Technology & Science (BITS), Pilani is an all-India Institute for higher education. The primary motive of BITS is to “train young men and women able and eager to create and put into action such ideas, methods, techniques and information”. The Institute is a dream come true of its founder late Mr G.D.Birla – an eminent industrialist, a participant in Indian freedom struggle and a close associate of the Father of Indian Nation late Mr. Mohandas Karamchand Gandhi (Mahatma Gandhi).

    Applications are invited from the eligible candidates to work as Junior Research Fellow (JRF) in Science and Engineering Research Board (SERB), DST, Govt of India sponsored projects at Department of Pharmacy, BITS Pilani, Pilani Campus.

    Post : JRF

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