Improving the Design of mRNA-loaded Nanocarriers for Targeted Therapies
Substituting amines with phosphonium-based cations could greatly improve the performance of mRNA-loaded polymeric micelles, report scientists from Tokyo Tech. By adopting this innovative strategy, they managed to enhance the stability and mRNA-delivery capabilities of micelle nanocarriers into tumor tissue in vivo. Their results hint at the importance of exploring other cations besides amines in mRNA drug delivery and could pave the way to effective treatment for challenging diseases.