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Inflammatory signs for adolescent depression differ between boys and girls


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Inflammatory signs for adolescent depression differ between boys and girls

New research led by the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King’s College London has found that depression and the risk of depression are linked to different inflammatory proteins in boys and girls.

When inflammation occurs in the body a host of proteins are released into the blood called cytokines. Previous research has shown that higher levels of cytokines are associated with depression in adults, but little is known about this relationship in adolescence.

Researchers investigated sex-differences in the relationship between inflammatory proteins and depression. Published in the Journal of Affective Disorders, the study found that different cytokines were implicated in depression risk and severity in boys compared to girls. The research was part of the IDEA (Identifying Depression Early in Adolescence) project funded by MQ Mental Health Research.

To assess inflammation, researchers measured the blood cytokine levels in 75 adolescent boys and 75 adolescent girls (aged 14-16 years) from Brazil. The 150 participants had been recruited into three groups with equal numbers (50 participants in each group: 25 girls and 25 boys). The groups were those at low-risk for depression and not depressed, those at high risk of depression and not depressed, and those currently experiencing major depressive disorder (MDD).

The findings indicated that there are sex differences between the individual inflammatory proteins that are associated with depression in adolescents. Higher levels of the cytokine interleukin-2 (IL-2) were associated with both increased risk for depression and the severity of depressive symptoms in boys, but not in girls. However, higher levels of IL-6 were associated with severity of depression in girls, but not boys. In boys the levels of IL-2 were higher in the high-risk than the low-risk group and even higher in the group diagnosed with depression, indicating that in boys IL-2 levels in the blood could help indicate the onset of future depression.

Researchers recruited adolescents from public schools in Brazil. Risk of depression was assessed by a composite risk score for depression based on 11 sociodemographic variables that had been developed as part of the IDEA project. Adolescents completed several questionnaires, self-reporting their emotional difficulties, relationships, experiences, and mood. They also completed a clinical assessment with a child and adolescent psychiatrist.

The study is part of the Identifying Depression Early in Adolescence (IDEA) project, led by Professor Valeria Mondelli at King’s IoPPN and funded by MQ Mental Health Research. The IDEA project is investigating how cultural, social, genetic and environmental factors lead to the development of depression in 10–24-year-olds across the UK, Brazil, Nigeria, Nepal, New Zealand and USA.

The study received support from the charity MQ Mental Health Research, UK Medical Research Council and the Academy of Medical Sciences. Professor Valeria Mondelli is supported by the National Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London and the Medical Research Council.