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New Antiprion Drug Polythiophene may treat mad Cow Disease

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Researchers found In the fight against bovine spongiform encephalopathy, the incurable brain-wasting disease also known as mad cow disease, a new drug compound could lead to a breakthrough.

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Scientists said the new antiprion drug, known as polythiophene, has proven highly effective in mice in blocking toxic, misfolded prions. Prions have been linked to dementia, personality shifts and other disorders, including Creutzfeldt-Jakob disease -- the human equivalent of mad cow disease. At present, no medication has proven effective in preventing or curing those neurodegenerative ailments.

But research in the American journal Science Translational Medicine said the new anti-prion compound appears to be successful in locking infectious clumps of prions in place. Researchers said infectious prions replicate by triggering normal forms of the protein to fold abnormally and cluster into long chains that are highly toxic to neurons.

The mice and hamsters treated with the compound showed fewer prion clusters and less severe damage in the brain, the scientists said, suggesting that it stabilized small clusters of prions and locked them in place, preventing self-replication.  The encouraging results suggest that polythiophene could prove to be a potent future treatment for prion diseases, according to the study.

Hermann is affiliated with the Institute for Neurology at the University of Zurich in Switzerland. Another key researcher on the study was Anja Boeckmann, at the Institute for Biology and Chemical Proteins at the University of Lyon in France.


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