About Authors:
M.Sateesh Kumar, C.Aparna*, Nalini Shastri, M.Sadanandam.
Department of Pharmaceutics, Sri Venkateshwara College of pharmacy,
Madhapur, Hyderabad-500081, India.
*sateeshmkt@gmail.com
Abstract:
Ropinirole hydrochloride buccoadhesive bilayered tablets containing bioadhesive layer and drug free backing layer were formulated to release the drug for extended periods of time with reduction in dosing frequency. The tablets were prepared by direct compression method using bioadhesive polymers like Carbopol934P, Methocel K4M, Methocel K15M, Sodium carboxy methyl cellulose, PVP K-30, Sodium alginate and Hydroxy propyl cellulose alone or in combination, Ethylcellulose has incorporated as an impermeable backing layer. Tablets were evaluated for weight and content uniformity, thickness, hardness, surface pH, swelling index, exvivo mucoadhesion time, invitro drug release and invitro drug permeation. The modifiedinvitro assembly was used to determine and compare the bioadhesive strength of tablets with fresh porcine buccal mucosa as a model tissue All characteristics of formulated tablets were shown to be dependant on composition of bioadhesive materials used. Maximum bioadhesion strength was observed for tablets formulated with Carbopol 934P. Carbopol 934P and Methocel K4M in the ratio of 1:1 could be used to design effective and stable buccoadhesive tablets of ropinirole hydrochloride.
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