B.Pharm

1. Which of the following factors most significantly affects the bioavailability of a poorly water-soluble drug in an oral solid dosage form?
A. Tablet hardness
B. Particle size reduction
C. Lubricant concentration
D. Compression pressure

2. The Higuchi model for drug release from a matrix system assumes which of the following conditions?
A. The drug concentration in the matrix is less than its solubility
B. The rate of dissolution is faster than diffusion
C. The system is diffusion-controlled