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Why synonymous mutations are not always silent

New modeling shows how synonymous mutations those that change the DNA sequence of a gene but not the sequence of the encoded protein can still impact protein production and function. A team of researchers led by Penn State chemists modeled how genetic changes that alter the speed of protein synthesis, but not the sequence of amino acids that comprise the protein, can lead to misfolding that changes the protein’s activity level, and then corroborated their models experimentally.

The off-patent drug that could protect us from future COVID-19 variants

Scientists have identified a drug that can be repurposed to prevent COVID-19 in research involving a unique mix of ‘mini-organs’, donor organs, animal studies and patients.

Novartis Pluvicto shows free survival benefit in patients with prostate cancer

Novartis announced the pivotal Phase III PSMAfore study with PluvictoTM (INN: lutetium (177Lu) vipivotide tetraxetan), a prostate-specific membrane antigen (PSMA)-targeted radioligand therapy, met its primary endpoint. Pluvicto demonstrated a statistically significant and clinically meaningful improvement in radiographic progression-free survival (rPFS) in patients with PSMA–positive metastatic castration-resistant prostate cancer (mCRPC) after treatment with androgen-receptor pathway inhibitor (ARPI) therapy, compared to a change in ARPI1.

Health ministry specifies Non clinical testing methods for new drug

The Ministry of Health and Family welfare amended the New Drugs and Clinical Trials Rules, 2019 in consultation with the Drugs Technical Advisory Board, DTAB, and specified non-clinical testing methods to assess the safety and efficacy of a new drug or investigational new drug.

Opportunity for M.Pharm as Junior Materiovigilance Associate at PGIMER

The PGIMER owes its inception to the vision of late Sardar Partap Singh Kairon, the then Chief Minister of Punjab and the distinguished medical educationists of the then combined state of Punjab, supported by the first Prime Minister of India Pt. Jawahar Lal Nehru who considered the institutions of scientific knowledge as temples of learning and the places of pilgrimage.

Post : Junior Materiovigilance Associate

Vacancy for Ph.D, M.Pharm, M.Sc as Technical Assistant at IIT Hyderabad

Our laboratory at IIT Hyderabad (with collaboration with hospital) leading by highly energetic interdisciplinary peoples, is working at the interface between materials and biology to develop next-generation nanotechnology approaches for health care products, which is unique and effective. We are seeking talented, motivated and passionate individuals (1 no) to join in our efforts for cutting-age research on “Nano-formulation Based Innovative Health Products”. The candidate will get highly interdisciplinary work environment to perform cutting age research.

WHO Internship Programme

WHO is the directing and coordinating authority for health within the United Nations system. It is responsible for providing leadership on global health matters, shaping the health research agenda, setting norms and standards, articulating evidence-based policy options, providing technical support to countries and monitoring and assessing health trends.

DBT/Wellcome Trust India Alliance invites applications for Adviser

DBT/Wellcome Trust India Alliance is a Public Charitable Trust registered in India since 2008. It is funded by the Wellcome Trust, UK, and the Department of Biotechnology, Government of India, with the broad aim of building excellence in biomedical research in India by selecting and supporting future leaders in the field. IA has recently started Phase 2 (2019-24) with expanded operations to include Team Science Grants, Clinical Research Centres, and allied activities.

Life Sciences recruitment at NIANP

The National Institute of Animal Nutrition and Physiology (NIANP) was established on 24th November 1995 at Bangalore under the aegis of Indian Council of Agricultural Research (ICAR), New Delhi. The Institute is mandated to conduct basic and fundamental research with respect to animal feed resource management using physiological-nutritional approaches to improve animal productivity and profitability of livestock farmers.

Post : Senior Research Fellow - 01 Post

Production, QA, QC, Packing Jobs at Hetero Drugs

Hetero Drugs is an Indian pharmaceutical company and the world’s largest producer of anti-retroviral drugs. Hetero’s business includes APIs, generics, biosimilars, custom pharmaceutical services, and branded generics. Globally renowned, vertically integrated pharmaceutical player engaged in Research and Development (R&D), manufacturing, and marketing of high-quality chemical and biologic medicines across diverse therapeutic areas.

Vacancy for Junior Research Fellow at BITS

Goa is a well-known and popular hotspot on the tourist map of India and the world. The name immediately brings to one’s mind the lush green meadows, hills and valleys, the sea and its attractive beaches. This charm and beauty sets the right ambience for BITS, Pilani  K K Birla Goa Campus, an Institute of excellence in Technology and Sciences.

Post : Junior Research Fellow

Walk in interview for B.Pharm in Production, QA, Packing at FDC Ltd

FDC is a people-oriented organization, dedicated to innovate, manufacture and market high-quality healthcare products that enhance the quality of human life all over the globe, and in turn, increase shareholders value.

Walk-In Interview for Goa I & II Location.

Job for BPharm, MPharm with MBA as Product Manager at Zydus Lifesciences

After a journey of growth spanning 27 years as Cadila Healthcare Ltd. and the Zydus Group, we have evolved and transformed ourselves in response to the changing times. Our legacy of over 70 years in healthcare and being dedicated to life in all its dimensions is reaffirmed in our new mission, vision and purpose. Unifying ourselves under the Zydus name, Cadila Healthcare Ltd., is renamed as Zydus Lifesciences Ltd.

Post : Product Manager

Hiring for Bioanalytical department at Veeda Clinical Research

Veeda Clinical Research Limited together with its subsidiary, Bioneeds India Private Limited and its joint venture, Ingenuity Biosciences Private Limited,  (together referred to as the Veeda Group) offers a comprehensive portfolio of clinical, preclinical and bio/analytical services to support innovator, biosimilar and generic drug development programs of our global clientele.

Walk in recruitment drive We are hiring for our Bioanalytical department.

Require Senior Manager - Regulatory Affairs at P&G

P&G was founded over 180 years ago as a simple soap and candle company. Today, we're the world’s largest consumer goods company and home to iconic, trusted brands that make life a little bit easier in small but meaningful ways. We've spanned three centuries thanks to three simple ideas: leadership, innovation and citizenship. The insight, innovation and passion of hardworking teams has helped us grow into a global company that is governed responsibly and ethically, that is open and transparent, and that supports good causes and protects the environment.

Teva inviting applications for Regulatory Associate

Teva is a global pharmaceutical leader and the world’s largest generic medicines producer, committed to improving health and increasing access to quality health solutions worldwide. Our employees are at the core of our success, with colleagues in over 80 countries delivering the world’s largest medicine cabinet to 200 million people every day. We offer a uniquely diverse portfolio of products and solutions for patients and we’ve built a promising pipeline centered around our core therapeutic areas.

Nanotech strategy shows promise for treating autoimmune disease

Scientists at Scripps Research have reported success in initial tests of a new, nanotech-based strategy against autoimmune diseases.

The scientists, who reported their results on November 23, 2022, in the journal ACS Nano, engineered cell-like “nanoparticles” that target only the immune cells driving an autoimmune reaction, leaving the rest of the immune system intact and healthy. The nanoparticles greatly delayed, and in some animals even prevented, severe disease in a mouse model of arthritis.

Peanuts and herbs and spices may positively impact gut microbiome

Adding a daily ounce of peanuts or about a teaspoon of herbs and spices to your diet may affect the composition of gut bacteria, an indicator of overall health, according to new research from Penn State. In two separate studies, nutritional scientists studied the effects of small changes to the average American diet and found improvements to the gut microbiome.

Scientists reveal encouraging findings in first-in-human clinical trial evaluating HIV vaccine approach

While scientists have struggled in the past to create an effective vaccine against HIV, a novel vaccine design strategy being pursued by researchers at Scripps Research, IAVI, Fred Hutchinson Cancer Center (Fred Hutch) and the National Institutes of Health, National Institute of Allergy and Infectious Diseases (NIAID) Vaccine Research Center (VRC) shows new promise, according to data from a first-in-human clinical trial.

Lupin Launches Rufinamide Tablets USP in the United States

Lupin is an innovation-led transnational pharmaceutical company headquartered in Mumbai, India. The Company develops and commercializes a wide range of branded and generic formulations, biotechnology products, and APIs in over 100 markets in the U.S., India, South Africa, and across the Asia Pacific (APAC), Latin America (LATAM), Europe, and Middle East regions.

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