Memory Enhancing Activity of Methanolic Extract of Selaginella Bryopteris in Swiss Albino Mice
About Author: Neeraj Kumar Garg*1, Pankaj Khatri1, Sangeeta Gupta2, N. Ganesh2
1. School of pharmacy, Suresh Gyan Vihar University, Mahal, Jagatpura, Jaipur (Raj.)
2. Incharge, Department of research, jawahar lal Nehru cancer Hospital and Research centre, Idgah hills Bhopal 462001 (M.P.)
Abstract
Alzheimer disease (AD) is a neurodegenerative disorder currently without an effective treatment. Impairment of memory is the initial and most significant symptom of Alzheimer disease (AD). The present study was under taken to investigate the effect of Selaginella bryopteris (popularly known as sanjeevani, Family: Selaginellaceae) on learning and memory. Two doses (250 and 500 mg/kg p.o.) of methanolic extract of Selaginella bryopteris were administered for 7 successive days in separate group of animals. The dose of 500 mg/kg p.o. of the methanolic extract of Selaginella bryopteris significantly improved learning and memory of mice. Antioxidant property of Selaginella bryopteris may be contributing favourably to the memory enhancement effect. However, further studies are necessitated to identify the exact mechanism of action. In the present investigation of Selaginella bryopteris have shown promising memory enhancing agent in the entire laboratory models employed.
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