About Authors:Dhaval Patel*^[1], Pratham Rathore^[1], Prerna Sharma^[1], Dr. Pankaj Shah^[2]
1 Department of Pharmacy Practice,
School of Pharmaceutical Sciences,
Jaipur National University,
Jaipur -302025, (Rajasthan), India
2 Institute of kidney disease and research center,
civil hospital, Ahmedabad, (Gujarat), India

Abstract
Inpresent study, comorbidities and laboratory abnormalities of lamivudine was analysed in hepatitis b patients. Clinical data were collected from hepatitis b patients that presented with laboratory abnormalities to lamivudine. We examined 100 patients of hepatitis b who treated with lamivudine in i.k.d.r.c, civil hospital, Ahmedabad from January 2009 to February 2011. The main laboratory abnormalities were elevation of creatine kinase, elevation of AST, elevation of serum lipase. Hypertension was the major comorbidities with the hepatitis b. The laboratory abnormalities were related to lamivudine, but the biological mechanism of the reaction is not clear.

HEALTH AND FAMILY WELFARE DEPARTMENT
HIMACHAL PRADESH.
FORM FOR THE NOTIFICATION OF VACANCIES TO THE EMPLOYMENT EXCHANGES.

Post: Pharmacist (On contract)

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IIT Bombay, set up by an Act of Parliament, was established in 1958, at Powai, a northern suburb of Mumbai. Today the Institute is recognised as one of the centres of academic excellence in the country. Over the years, there has been dynamic progress at IIT Bombay in all academic and research activities, and a parallel improvement in facilities and infrastructure, to keep it on par with the best institutions in the world. Institutes in positions of excellence grow with time.

North-East Institute of Science & Technology, Jorhat, a constituent establishment of CSIR, is a multidisciplinary institute having research areas like Medicinal Chemistry, Natural Products Chemistry, Synthetic Organic Chemistry, Biotechnology, Medicinal, Aromatic and Economic plants, Geoscience, Petroleum & Natural Gas, Applied Civil Engineering, Chemical Engineering, General Engineering, Cellulose Pulp & Paper, Material Science, Coal, etc.

The University of Louisville is a state supported research university located in Kentucky's largest metropolitan area. It was a municipally supported public institution for many decades prior to joining the university system in 1970. The University has three campuses. The 287-acre Belknap Campus is three miles from downtown Louisville and houses seven of the university's 11 colleges and schools.

Syngene International is one of India’s premier contract research and manufacturing organizations in providing customized service. Our services encompasses all across discovery chain: early stage discovery, process development, cGMP manufacturing and formulation development both in the small molecule and novel biologics area.

The National Centre for Cell Science (NCCS) took birth as National Tissue Culture Facility in March 11, 1986 with a mandate of basic research, teaching & training, and as a national repository for cell lines/hybridomas etc.  The centre is located in the midst of academically enriched environment of University of Pune campus, Pune.

Mahatma Gandhi University, one of the four affiliating universities in Kerala, is the premier educational institution that strives to fulfil the higher educational needs of the people of Central Kerala. Set on the sprawling 110-acre campus called Priyadarshini Hills at Athirampuzha, 13 kms off Kottayam, the University also has seven satellite campuses in parts of Kottayam and the neighbouring districts.

About Authors:
Sukanto Paul, Krishan R Bhadu
Department of Quality Assurance, School of Pharmaceutical Sciences,
Jaipur National University,
Jagatpura, Jaipur-302025,
Rajasthan, India.

ABSTRACT
A validated reverse phase high performance liquid chromatography method has been developed for the simultaneous determination of Tirofiban hydrochloride in pure and marketed formulation. Chromatography was carried out on a BDS Hypersil C18 (4.6 mm × 250 mm, 5 μm) using Buffer: Acetonitrile in the ratio of 80:20 (v/v) as the mobile phase at a flow rate of 1.5 mL/min and eluents were monitored at 274 nm using UV detector at ambient temperature.  The average retention time of Tirofiban was found to be 9.124 min. The method was validated for linearity, precision, accuracy, specificity, robustness and solution stability. The calibration curve was linear (R²≥0.9999) over the range of 12.5-75 μg/mL.Limit of detection (LOD) and Limit of quantitation (LOQ) were 0.11 μg/mL and 0.33 μg/mL respectively. This method can be successfully employed for the quantitative analysis of Tirofiban hydrochloride in bulk drugs and formulations.

About Authors:
Garg Pushpendra, Nanda Arun
Department of Pharmaceutical Sciences
Maharshi Dayanand University, Rohtak-124001
Haryana, India.

ABSTRACT
The objective of the present study was to improve the dissolution rate of gliclazide, a poorly water soluble (BCS class-II) drug by solid dispersion technique using a water soluble carrier, poloxamer 407. The solid dispersions were prepared by fusion method using different concentrations of carrier and the prepared systems showed an enhancement in dissolution. Solid dispersions were characterized with Differential scanning calorimetry, X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy and dissolution analysis. The study revealed that enhanced dissolution of gliclazide from solid dispersion was due to a decrease in crystallinity of drug and also due to dissolution of gliclazide in molten form of solid dispersion. In conclusion preparation of gliclazide dispersion with meltable hydrophilic polymer could be a promising approach to improve the dissolution rate.

About Author: G. Anand Rao*, V. Venu, R. Senthil Selvi, P. Perumal,
Department of Pharmaceutics,
J. K. K. Nattraja College of Pharmacy,
Komarapalayam - 638 183, Namakkal (D.T),
Tamil Nadu, India

Abstract
The main objective of the present work was to develop sustained release matrix tablets of Lornoxicam using Hydrophilic polymers viz. Hydroxy propyl methyl cellulose (HPMC K4M, HPMC K10M, HPMC K15M) was developed using wet granulation technique at varying ratios of drug and polymer like 1:1, 1:2 and 1:3 were selected for the study. Micro crystalline cellulose and Lactose was added in this formulation as a function of binder and diluent. Prior to compression, the prepared granules were evaluated for flow and compression characteristics. After evaluation of physical properties of tablet, the in vitro release study was performed in 0.1 N Hcl, pH 1.2 for 2 hrs and in phosphate buffer pH 6.8 up to 12 hrs. The effect of polymer concentration and polymer blend concentration were studied. Dissolution data was analyzed by Korsmeyer- Peppas law expression. It was observed that matrix tablets contained polymer HPMC K10M was successfully sustained the release of drug up to 12 hrs. Among all the formulations, formulation F9 which contains 1:3 ratios of drug and polymer release the drug which follows Zero order kinetics via, swelling, diffusion and erosion. Stability studies (40±2oc/75±5%RH) for three months indicated that Lornoxicam was stable in the matrix tablets. The FTIR study revealed that there was no chemical interaction between drug and excipients.

About Author: Manoj Dupati, Shiva Kumar, Sharadamma K. C. and Radhakrishna P. M.
Provimi Animal Nutrition India Pvt Limited,
Yelahanka New Town, Bangalore – 560 106,
Karnataka, India

Plants have provided human beings for all needs in terms of shelter, clothing, food, ?avours and medicines. In particular plants have formed the basis of sophisticated traditional medicine systems like Ayurvedic, Unani, and Chinese amongst others. These systems of medicine have given rise to some important drugs which are being used in modern medicine too. This article highlights and provides an overview of the classes of molecules present in plants having specific biological activity and finds use as feed additives ensuring better health and productivity of live stock.

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Govt. of Himachal Pradesh took up initiative in early seventies to set up a CSIR lab to make prudential use of the natural resources of the region. After several levels of discussions a formal request was made by then Chief Minister of HP to Vice President, CSIR in 1982 for initiating the matter, and giving final shape to the proposal.

WHO is the United Nations’ specialized agency for Health. It is an inter-governmental organization and works in collaboration with its member states usually through the Ministries of Health. WHO’s objective is the attainment by all people of the highest possible level of health. WHO's Secretariat is staffed by health professionals, other experts and support staff working at headquarters in Geneva, six regional offices and country offices.

Cipla known for its innovative pharmaceutical products backed by latest in technology and creative marketing practices, is enjoying a commanding position among the top pharma companies in the country.
Several specialised therapeutic divisions and promising new products have been launched and many more are in the pipeline.

National Institute of Pharmaceutical Education and Research (NIPER) is the first national level institute in pharmaceutical sciences with a proclaimed objective of becoming a centre of excellence for advanced studies and research in pharmaceutical sciences. The Government of India has declared NIPER as an ‘Institute of National Importance’.

Public Service Commissions, both at the Union and at the State level, are amongst the most important Public Institutions with long traditions which have served well. The establishment of this Institution had its origin in the history of Indian nationalism and the persistent demand of the leaders of freedom movement for progressive Indianisation of the Civil Service under British Raj.

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