DEVELOPMENT OF DOMPERIDONE NASAL GEL USING NATURAL MUCOADHESIVE AGENT OBTAINED FROM THE FRUITS OF DELLINIA INDICA. L.
About Authors:
Dharmendra Kumar*, BhanuPriya, S.K Gupta
*Department of Pharmaceutical Technology,
Meerut Institute of Engineering and Technology,
Meerut, Uttar Pradesh, India, 250005
*rvnimiet@gmail.com
Abstract.
The aim of this research work was replaced the tablet or injection of Domperidone by using domperidone nasal gel forrmulations. In research, day to day newer novel drug delivery comes for various drugs nasal gel drug delivery system one of them. Purpose of this study is formulating a nasal gel of Domperidone by using natural mucoadhesive agent extract from Dellinia Indica. In vitro drug release study carried out by using Franz-diffusion cell and excised bovine nasal membrane,characterisation was also found to be better in comparison to the HPMC and carbapolsynthetic polymers. Dellinia indica has valuable properties as a mucoadhesive agent because it is considered to be biocompatible, biodegradable and non-toxic. In future nasal gel formulations replace tablet/injection of Domperidone.