Phytochemical, In Vitro and In Silico Evaluation on Clitoria Ternatea for Alzheimer’s Disease

  • Posted on: 1 September 2014
  • By: admin

 

 

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PharmaTutor (September- 2014)
ISSN: 2347 - 7881
(Volume 2, Issue 9)

 

Received On: 20/06/2014; Accepted On: 24/06/2014; Published On: 01/09/2014

 

AUTHORS: Nadia Shahnas*, Akhila.S
Department of pharmaceutical chemistry,
University College of Pharmacy (RIMSR),
Puthupally, Kottayam, Kerala, India
nadiya.ameer@gmail.com

 

ABSTRACT:
Alzheimer’s disease (AD) is a complex, multifactorial, progressive, neurodegenerative disease primarily affecting the elder population and is estimated to account for 50–60% of dementia cases in persons over 65 years of age. Natural products, including plants, animals and minerals have been the basis of treatment of human diseases. Secondary metabolites have been the most successful source of potential drug leads and continue to provide unique structural diversity in comparison to standard combinatorial chemistry, traditional medicinal practices have formed the basis of early medicines followed by subsequent clinical, pharmacological and chemical studies which provides opportunities for discovery for many novel low molecular weights lead compounds. In silico approach has been of great importance as a versatile tool to develop fast and accurate target identification and prediction method for the discovery. Traditionally docking was used as computational tool for screening databases of natural products to mine a set of a few candidate drug-like compounds. Reverse docking was a comparatively new application of docking in which a database of proteins (drug targets) was docked against a set of natural products to predict binding affinities. Therefore, plant extracts may in future provide more effective medicines than the single purified natural products of modern medicine, in some cases. Studies on identification of compounds from traditionally used medicinal plants to cure neurodegenerative diseases and brain injuries is increasing scientific interest in recent years as this a major concern in public. In Ayurveda the roots, seeds and leaves of Clitoria ternatea have been widely used as brain tonic and believed to promote memory and intelligence. Hence the present study was designed to assess the Alzheimer’s activity of Clitoria ternatea and to identify and isolate the major bioactive constituent attributing the activity.

 

How to cite this article: N Shahnas, S Akhila; Phytochemical, In Vitro and In Silico Evaluation on Clitoria Ternatea for Alzheimer’s Disease; PharmaTutor; 2014; 2(9); 135-149

 

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