A Review on Lyophilization: A Technique to Improve Stability of Hygroscopic, Thermolabile Substances

  • Posted on: 31 October 2017
  • By: admin

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PharmaTutor (November - 2017)

 

ISSN: 2347 - 7881
(Volume 5, Issue 11)

 

Received On: 10/07/2017; Accepted On: 14/07/2017; Published On: 01/11/2017

 

AUTHORS:
Shivanand *A, Sayantan Mukhopadhayaya
Division of Pharmaceutical Sciences
S.G.R.R.I.T.S,
Dehradun, Uttarakhand, India.
*shiva3671@gmail.com

 

 

ABSTRACT:
The active pharmaceutical ingredient that is thermolabile and moisture sensitive in nature generally degraded in atmospheric condition and thus have reduced stability and self-life. Lyophilization is one of those techniques which is utilized effectively to improve such critical condition. It is the one of the emerging technology in themodern era, which is effectively involved in the preparation of several antibiotics (e.g., chloramphenicol, doxycycline) and anti-cancer drugs (e.g., doxorubicin, epirubicin). This technique effectively utilized the phenomenon of sublimation to obtained primary dried product followed by removal of excess amount of moisture by modulation of heat. This technique not only improved self-life of thedrug but also provides fast reconstitution and reduced the cost of storage and shipping. Inthis review article principle behind lyophilization, steps involved, formulation aspects, theimportance of lyophilization and detection of the end point in lyophilization along with recent advancementwas explained.

 

 

How to cite this article: Shivanand A, Mukhopadhayaya S; A Review on Lyophilization: A Technique to Improve Stability of Hygroscopic, Thermolabile Substances; PharmaTutor; 2017; 5(11); 28-39

 

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