A Review on Pharmacology of Combined Edaravone and Argatroban Therapy in Acute Ischemic Stroke
PharmaTutor (November- 2014)
ISSN: 2347 - 7881
(Volume 2, Issue 11)
Received On: 26/08/2014; Accepted On: 07/09/2014; Published On: 01/11/2014
AUTHORS: Patel Divya A*., Varodiya Priyanka S., Raj Hasumati A.
Department of Quality Assurance, Shree Dhanvantary Pharmacy College,
Kim, Surat, Gujarat, India
This review article presents the pharmacology of combined edaravone and argatroban therapy especially in acute ischemic stroke. Edaravone (MCI-186) is a free radical scavenger, a novel neuroprotective agent. Argatroban is a selective thrombin inhibitor. The antithrombotic agent was used in acute cerebral infarction. If the antithrombotic agent is administered in large quantities, the condition of patient become worse by occurrence of adeverse effect of cerebral haeorrhage. The use of edaravone in combination with antithrombotic agent has been proved to provide beneficial effect in acute ischemic stroke as edaravone has no influence to coagulation of blood and platelets aggregation. The combination therapy has fewer hemorrhagic adeverse effect. The mechanism of argatroban and edaravone is quite different. Argatroban, an anti-coagulant drug, directly improves the microcirculation of ischemic brain tissue while edaravone could indirectly attenuated brain edema by protection of endothelial cells damaged by free radicals generated after ischemic insult. The combination of both would have reciprocal and enhanced neuroprotective effects against ischemic insult. Both the drugs were approved by Japanese government and has been used in acute brain infarction in japan. The main objective of this review article is to provide pharmacological information of combined therapy of edaravone and argatroban to researcher in development of combined dosage form of this.
How to cite this article: DA Patel, PS Varodiya, R Hasumati; A Review on Pharmacology of Combined Edaravone and Argatroban Therapy in Acute Ischemic Stroke; PharmaTutor; 2014; 2(11); 42-49