A Review of Analytical Methods for Determination Bromhexine Hydrochloride in Pharmaceutical and Biological Samples

  • Posted on: 1 November 2014
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PharmaTutor (November- 2014)

 

ISSN: 2347 - 7881
(Volume 2, Issue 11)

 

Received On: 10/09/2014; Accepted On: 19/09/2014; Published On: 01/11/2014

 

AUTHORS: Meera V. Lad1*, Vineet Jain2, Hasumati Raj1
1Department of Quality Assurance,
2Department of Pharmacognosy,
Shree Dhanvantary Pharmacy College, Kim, Gujarat
meeralad235@gmail.com

 

ABSTRACT:
Bromhexine HCl (BRH)is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus, chemically named 2-amino-3,5-dibromo-N-cyclohexyl-N-methyl benzenemethanamine hydrochloride. According to IUPAC it is 2,4-dibromo-6-[[cyclohexyl(methyl)amino]methyl] aniline hydrochloride. Because of its physiological importance, the drug has been quantified by exploiting its chemical  and physical properties. Bromhexine is a weak base and its precipitate out at pH value above 6. Bromhexine is a synthetic benzyl amine derivative ofvasicine. The different analytical methods used to quantify the drug as a single active pharmaceutical ingredient include flow injection analysis with ion selective electrodes, inductively coupled plasma mass spectrometry, electrokinetic chromatography, electrochemical oxidation at the glassy carbon electrode, liquid chromatography, liquid gas chromatography, GC with mass detection, and voltammetry. The drug has also been quantified in its combined formulations using HPLC, direct and derivative UV spectrophotometry.

 

How to cite this article: MV Lad, V Jain, R Hasumati; A Review of Analytical Methods for Determination Bromhexine Hydrochloride in Pharmaceutical and Biological Samples; PharmaTutor; 2014; 2(11); 35-41

 

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