New Spectrophotometric Method Development and Validation of Lumefantrine

  • Posted on: 1 May 2014
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PharmaTutor (May- 2014)
ISSN: 2347 - 7881

 

Received On: 04/03/2014; Accepted On: 16/03/2014; Published On: 01/05/2014

 

Author: Baokar Shrikrishna1*, Annadate Amol1, Undare Santosh2
1Department of Pharmaceutical Chemistry, SVPM’s College of Pharmacy, Malegaon (Bk II), Baramati, Pune, Maharashtra, India
2P.G. Department of chemistry, Balbhim arts, science and commerce college, Beed
krishnabaokar@gmail.com

 

ABSTRACT:
A Simple, sensitive, specific, spectrophotometric method has been developed for the detection of Lumefantrine in pure and Pharmaceutical formulations. The optimum condition for the analysis of the drug was established. Lumefantrine shows maximum absorption at 228 nm and obeyed beers law in the concentration range 10 to 50 µg/ml.
The correlation coefficient was found to be 0.999 and slope of line was found to be 0.0635. The percent S.D. for intra assay precision of the method was found to be 1.85% whereas Inter assay precision was found to be 0.44%. The sample solution was stable up to 24 hours. The assay results were found to be in good agreement with label claim.
The proposed method was simple sensitive, precise, quick and useful for routine quality control.

How to cite this article: SK Baokar, A Annadate, S Undare; New Spectrophotometric Method Development and Validation of Lumefantrine; PharmaTutor; 2014; 2(5); 148-154

 

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