Invitro and In Vivo Evaluation of Anticancer Activity of Boerhaavia Diffusa Linn in Experimental Animals
PharmaTutor (May- 2014)
ISSN: 2347 - 7881
Received On: 29/03/2014; Accepted On: 04/04/2014; Published On: 01/05/2014
Author: Nandu Kayande1*, Pankaj Kushwah2
1Department of Pharmacology
2Department of Pharmacognosy
Nimar Institute of Pharmacy,
Dhamnod, Dhar, Madhya Pradesh, India.
The antitumor activity of the ethanolic extract of leaves of boerhaavia diffusa L. (EBD) has been evaluated against Dalton’s ascitic lymphoma (DAL) in Swiss albino mice at the dose of 250 & 500 mg/kg, body weight. The experimental parameters used were tumour volume, tumour cell count, viable tumour cell count, mean survival time and increase in life span to assess antitumour activity. The extract administered orally for 14 consecutive days to tumor bearing group of animals. The extract increase the life span of DAL treated mice and restore the hematological parameters as compared with the DAL bearing mice in dose dependant manner. The study revealed that the EBD showed significant antitumour activity in tested animal models.
How to cite this article: N Kayande, P Kushwah; Invitro and In Vivo Evaluation of Anticancer Activity of Boerhaavia Diffusa Linn in Experimental Animals; PharmaTutor; 2014; 2(5); 133-137