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Chronopharmacotherapy of Hypertension: Time-dependent effects of treatment on blood pressure


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PharmaTutor (March- 2015)


Print-ISSN: 2394 - 6679
e-ISSN: 2347 - 7881
(Volume 3, Issue 3)


Received On: 10/12/2014; Accepted On: 21/12/2014; Published On: 01/03/2015


AUTHORS: Suresh Rewar1*, Bansal BK1, Singh CJ2, Sharma AK2
Department of pharmaceutics, Arya College of Pharmacy, Jaipur, Rajasthan, India
Department of Pharmacology, Arya College of Pharmacy, Jaipur, Rajasthan, India


ABSTRACT: Chronopharmaceutical drug delivery systems are gaining a lot of interest as they deliver the drug at the right site of action, right time and right amount, as per the pathophysiological needs of the diseases. These systems are basically time-controlled drug delivery systems in which the system controls the lag time independent of environmental factors like pH, enzymes, GIT motility, etc. These systems are designed for chronopharmacotherapy which is based on the circadian rhythm of the body. The effectiveness and toxicity of many drugs vary depending on dosing time associated with 24 hr. rhythms of biochemical, physiological and behavioral processes under the control of circadian clock. The chronobiology of the various common 24-hour BP profiles seen in hypertensive patients in relation to cardiovascular risk and end-organ injury and ultimately the control and normalization of abnormal BP throughout daytime activity and night time sleep. Chronopharmacotherapy provides a means of individualizing the treatment of hypertension according to the circadian BP profile of each patient, and constitutes a new option to optimize BP control and to reduce the risk of cardiovascular disease. Various latest and upcoming marketed technologies of Chronopharmaceutical drug delivery used in treatment of hypertension diseases like OROS®, CODAS®, CEFORM®, DIFFUCAPS®, PULSINCAP® etc.


How to cite this article: S Rewar, BK Bansal, CJ Singh, AK Sharma; Chronopharmacotherapy of Hypertension: Time-dependent effects of treatment on blood pressure; PharmaTutor; 2015; 3(3); 18-23