Formulation and in-vitro Evaluation of Mouth Dissolving Tablets of Ketoprofen: Effect of Disintegrants on Drug Release

  • Posted on: 31 May 2017
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PharmaTutor (June - 2017)


ISSN: 2347 - 7881
(Volume 5, Issue 6)


Received On: 21/02/2017; Accepted On: 16/03/2017; Published On: 01/06/2017


Kambham Venkateswarlu*,
Department of Pharmaceutics,
JNTUA-Oil Technological and Pharmaceutical Research Institute
Andhra Pradesh,  India



The objective of the present investigation was to formulate and evaluate the mouth dissolving tablets (MDTs) of ketoprofen (KPN) using disintegrants like Crospovidone (CP), Croscarmellose sodium (CCS) and Sodium starch glycolate (SSG) and the effect of disintegrants on drug release was also studied. The powder blend was evaluated for flow properties and found acceptable flow properties. The prepared MDTs were evaluated for post compression parameters such as hardness, friability, weight variation, dispersion time, drug content and in-vitro drug release. Tablets possessing sufficient strength supported by hardness and friability results. The formulation KP6 showed lease dispersion time of 14 sec and it was selected for drug release studies.



How to cite this article: Venkateswarlu K; Formulation and in-vitro valuation of Mouth Dissolving Tablets of Ketoprofen: Effect of Disintegrants on drug release; PharmaTutor; 2017; 5(6); 17-21



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