Formulation and Evaluation of Metformin Hydrochloride buccal patch

  • Posted on: 30 June 2016
  • By: admin

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PharmaTutor (July- 2016)


Print-ISSN: 2394 - 6679
e-ISSN: 2347 - 7881
(Volume 4, Issue 7)


Received On: 08/02/2016; Accepted On: 22/02/2016; Published On: 01/07/2016


S. Z. Chemate, Vaishali N. Garje*, Shubhada A. Gayake
Department of Pharmaceutics,
Padmashri Dr. Vithhalrao Vikhe Patil Foundation’s College of Pharmacy,
Ahmednagar, Maharashtra, India


ABSTRACT: The aim of present investigation was to design and evaluate, mucoadhesive buccal patch of Metformin hydrochloride, a BCS class II drug, to provide unidirectional sustained drug delivery to the buccal mucosa that has potential to enhance the bioavailability. The patches were prepared using HPMC K4M as a polymer, polyethylene glycol 400 as a plasticizer, by solvent casting technique. The patches, which were prepared by the solvent casting method, were smooth and elegant in appearance; were uniform in thickness, weight and drug content; showed no visible cracks; and showed good folding endurance. The amount of polymer, which significantly influenced characteristics like swelling index, mucoadhesive strength, diffusion study.


How to cite this article: Chemate SZ, Garje VN, Gayake SA; Formulation and Evaluation of Metformin Hydrochloride buccal patch; PharmaTutor; 2016; 4(7); 52-58