PharmaTutor (July- 2014)
ISSN: 2347 - 7881
Received On: 17/04/2014; Accepted On: 30/04/2014; Published On: 01/07/2014
AUTHORS: Mehul Kakdiya*1, Viral M. Kakadiya2, Darshan Madiya1, Shital Faldu1
1Department of Quality Assurance, Smt. R. D. Gardi B. Pharmacy College, Rajkot, Gujarat, India
2Pacific college of pharmacy, Udaipur, Rajasthan
A simple, selective, rapid, precise and economical reverse phase high performance liquid chromatographic method has been developed for the simultaneous estimation of Paracetamol and Propyphenazone in their combined pharmaceutical dosage form. The method was carried out on a Inertsil ODS 3V (250 x 4.6 mm i.d., 5 μ) column with a mobile phase consisting of acetonitrile: water in the ratio of 70:30 v/v at a flow rate of 1.0 mL/min. Detection was carried out at 238 nm.
The retention times of Paracetamol and Propyphenazone were 5.87 and 13.63min, respectively. The developed method was validated in terms of accuracy, precision, linearity, limit of detection, limit of Quantitation. The proposed method can be used for the estimation of these drugs in routine quality control.
How to cite this article: M Kakdiya, VM Kakadiya, D Madiya, S Faldu; Analytical Method Development and validation for simultaneous Estimation of Paracetamol and Propyphenazone in their Combined Pharmaceutical dosage form by RP-HPLC Method; PharmaTutor; 2014; 2(7); 157-161
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