Resealed Erythrocytes as A Potential Drug Carrier: A Review
PharmaTutor (August- 2014)
ISSN: 2347 - 7881
(Volume 2, Issue 8)
Received On: 27/05/2014; Accepted On: 20/07/2014; Published On: 01/08/2014
AUTHORS: Tapan Behl*, Ishneet Kaur, Rashi Wanchoo Misri, Heena Goel
Senior Research Fellow, Department of Pharmacology,
Vallbhbhai Patel Chest Institute, University of Delhi, Delhi.
Drug delivery and drug targeting systems developed by various researchers are beleaguered to deliver the drug safely to the target sites without much interaction with other tissues of the body, so as to increase its bioavailability and reduce the adverse effects of that drug. In this approach, many drug carriers have been developed which are being widely used these days for increasing the efficacy and safety of the pharmaceutical products. Among the cellular carriers, the erythrocytes are the most potentiated drug carriers with very capitalizing properties like precise site specificity and sustained drug release. The circulation of erythrocytes into every corner of the human body is one such another advantage, thus making them useful for drugs which cannot be taken to their target site by any other carrier. Resealed erythrocytes are prepared by isolating erythrocytes from the plasma of the blood sample of an organism of interest, breakdown of cells using different methods and then entrapping the drug (which is to be administered into the body) into the erythrocytes by various techniques such as hypotonic haemolysis, hypotonic dilution, hypotonic pre-swelling method, dialysis method, isotonic osmocytosis, chemical perturbation of the membrane, electro-insertion method, entrapment by endocytosis, lipid fusion method etc., and then finally they are sealed back again, thus, accounting for their name – “Resealed Erythrocytes”.
How to cite this article: T Behl, I Kaur, RW Misri, H Goel; Resealed Erythrocytes as a Potential Drug Carrier: A Review; PharmaTutor; 2014; 2(8); 73-78