Solid Dispersion: A Tool to Enhance Solubility of Poorly Water Soluble Drugs

  • Posted on: 1 April 2014
  • By: admin

 

PharmaTutor (April- 2014)
ISSN: 2347 - 7881

 

Received On: 18/02/2014; Accepted On: 27/02/2014; Published On: 01/04/2014

 

Author: Ravindra M Hanwate*1, Dehghan MHG 2, Saifee M 2
1
Department of Pharmaceutics, Dr.Vedprakash Patil College of Pharmacy,
Auranganad, Maharashtra, India
2 Department of Pharmaceutics, Y.B.Chavan College of Pharmacy,
Aurangabad, Maharashtra, India
* ravi_hanwate@yahoo.co.in

 

ABSTRACT:
Solid dispersions have been used to increase the dissolution rates of poorly water soluble drugs. Many methods are used to prepare solid dispersions. This paper reports various solubility enhancement strategies in solid dispersion. The methods described are fusion (melting), solvent evaporation, lyophilization (freeze drying), melt agglomeration process, spray drying technology, use of surfactant. The paper also shows study of characterization, selection of carriers, potential applications and limitations of these methods in solid dispersion.

How to cite this article: RM Hanwate, MHG Dehghan, M Saifee, Solid Dispersion: A Tool to enhance solubility of Poorly Water Soluble Drugs, PharmaTutor, 2014, 2(4), 50-60

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