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Q.91    All of the given four drugs cause vasodilatation. Choose the correct statement about them.
[P] Bradykinin    [Q] Minoxidil     [R] Acetylcholine   [S] Hydralazine
(A)    P & Q cause release of nitric oxide
(B)    Q & R do not cause release of nitric oxide
(C)    R & S cause release of nitric oxide
(D)    P & S do not cause release of nitric oxide

Q.92    Blood level monitoring of HbAlc is important in which of the given diseased states?
(A)   Hypercholesterolemia    (B)   Diabetes mellitus
(C)   Myocardial infarction    (D)   Congestive heart failure

Q.93    Which of the fallowings is the most effective monotherapy for raising HDL cholesterol?
(A)   Statins    (B)   Niacin
(C)   Ezetimibe    (D)   α-3-Fatty acids

Q.94    Which of the following pairs has high binding affinity for Sa-reductase?
(A)   Letrozole and androstenedione    (B)    Finasteride and testolactone
(C)   Finasteride and 5-DHT                   (D)    Finasteride and testosterone

Q.95    Which is the molecular target for the vinca alkaloids as anticancer agents?
(A)   Tyrosine kinase    (B)   DNA
(C)   Ribosomes          (D)   Tubulin

Q.96    A 64 year old woman with a history of Type II diabetes is diagnosed with heart failure. Which of the followings would be a POOR choice in controlling her diabetes?
(A)   Metformin        (B)   Pioglitazone    (C)   Glipizide    .(D)   Exenatide

Q.97    Which of the following parameters from plasma concentration time profile study gives indication of the rate of drug absorption?
(A)     Cmax    (B)     Tmax    (C)     AUC    (D)     tl/2

Q.98    Which of the following skeletal    muscle relaxants acts directly on the contractile mechanism of the muscle fibers?
(A)   Pancuronium    (B)   Baclofen
(C)   Dantrolene    (D)   Chlorzoxazone

Q.99    Choose the correct pair of the neurodegenerative disorders from those given below.
(A)    Parkinson's disease and Alzheimer's disease
(B)    Schizophrenia and Mania
(C)    Alzheimer's disease and Schizophrenia
(D)    Parkinson's disease and Autism

Q.100  Mifepristone and gemeprost combination is used for medical termination of pregnancy. The action is caused due to which of the following mechanisms?
(A)    Mifepristone is an antiestrogen while gemeprost is a prostaglandin E receptor agonist.
(B)    Mifepristone is an antiprogestin while gemeprost is a prostaglandin E receptor agonist.
(C)    Mifepristone is an antiandrogen while gemeprost is a prostaglandin E receptor agonist.
(D)    Mifepristone is an antiprogestin while gemeprost is a prostaglandin E receptor antagonist.

Q.101   Upon standing sometimes gel system shrinks a bit and little liquid is pressed out. What is this phenomenon known as?    -
(A)   Oozing    (B)   Syneresis    (C)   Shrinking    (D)   Desolvation

Q.102   Study the following two statements and choose the correct answer: [P] Antibodies are serum proteins providing immunity.
[Q] IgG provides immunity to new born babies while IgM is the first generated antibody.
(A)   P is correct and Q is incorrect    (B)   P is incorrect and Q is correct
(C)   Both P and Q are correct            (D)   Both P and Q are incorrect

Q.103   Non-linear pharmacokinetics can be expected due to
[P]    Enzyme induction [Q]   Active secretion
Choose the correct answer.
(A)   Both P and Q are true    (B)   P is true, Q is false
(C)   Q is true, P is false    (D)   Both P and Q are false

Q.104  Which of the following statements is INCORRECT?
(A)    Chick Martin test uses organic matter in media
(B)    The organism in Rideal-Walker test is S. typhi
(C)    Rideal-Walker test uses organic matter in media
(B)    The organism in Chick Martin test is S. typhi

Q.105  Which of the following routes of administration of drugs is associated with Phlebitis?
(A)   Subcuteneous    (B)   Intravenous    (C)   Intraspinal       (D)   Intradural


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