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BSSC KARSHIM Pharmacy Question Paper - 2013

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1. Who is regarded the father of surgery in ancient India?
(A) Sushrutha (B) Charaka (C) Vasavadatta (D) Dhanvantari

2. How many bones are there in the normal adult human body?
(A) 201 (B) 204 (C) 206 (D) 210

3. Which of these is used in the treatment of malaria?
(A) Meflooquine (B) Azithromycin (C) Rabeprazole (D) Methotrexate

4. The organism responsible for AIDS is
(A) Hepatitis B virus (B) HIV (C) Herpes virus (D) Plasmodium

5. Which of the following routes of drug administration is not parenteral ?
(A) Intravenous (B) Subcutaneous (C) Intradermal (D) Sublingual

6. Beta blockers are used in treatment of
(A) Hypertension (B) (C) Myxedema (D) Diabetes mellitus Hypercholesterolemia

7. What is the primary use for pioglitazone ?
(A) Anti-convulsant (B) In Hypertension (C) In Diabetes (D) In Malaria

8. Fever with bodyaches and low platelet counts is likely to be
(A) Dengue (B) Typhoid (C) TB (D) Pneumonia

9. The process of transport across a cell in particulate form by formation of vesicles is called
(A) Active transport (B) Facilitated diffusion (C) Pinocytosis (D) Passive diffusion

10. When the rate of elimination of a drug remains constant irrespective of drug concentration, it is said to follow
(A) Zero order kinetics
(B) First order kinetics
(C) Exponential kinetics
(D) Secretory kinetics

11. Complete drug elimination occurs usually after
(A) 2 half lives (B) 3 half lives (C) 5 half lives (D) 10 half lives

12. Hit and Run’ drugs are
(A) Whose plasma concentration cannot be measured
(B) Whose effect lasts longer than the drug itself
(C) Those with short life
(D) Those withdrawn from market very fast

13. The longest bone in the body is
(A) Humerus (B) Stapes (C) Tibia (D) Femur

14. A drug which activates a receptor to produce effect in the opposite direction to that of a well recognized agonist is called
(A) Partial agonist (B) Antagonist (C) Super Agonist (D) Inverse agonist

15. Which is the largest organ in the body?
(A) Skin (B) Brain (C) Heart (D) Kidney

16. Cardiac output is the product of heart rate and
(A) Respiratory rate (B) Minute ventilation (C) Stroke volume (D) Peripheral resistance

17. Precordium refers to area overlying the
(A) Heart (B) Lungs (C) Stomach (D) Urinary bladder

18. The route of administration for insulin is
(A) Subcutaneous (B) Intramuscular (C) Intravenous (D) All

19. The cells in the blood responsible for carrying oxygen is
(A) WBC (B) RBC (C) Lymphocyte (D) Platelet

20. Energy from food sources is measured usually in
(A) Dyne (B) Calorie (C) Pascals (D) Horsepower

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21. The acid normally secreted in the human stomach is
(A) Nitric acid (B) Sulphuric acid (C) Hydrochloric acid (D) Citric acid

22. Who first showed the complete pathway of blood circulation ?
(A) William Harvey (B) Vesuvius
(C) Hippocrates (D) Alexander Fleming

23. The number of chambers in a normal human heart is
(A) 1 (B) 2 (C) 3 (D) 4

24. Human cells have pairs of sex chromosomes.
(A) 1 (B) 2 (C) 23 (D) 46

25. The organ predominantly involved in metabolism of drugs is
(A) Liver (B) Lungs (C) Stomach (D) Spleen

26. When a drug binds to a silent receptor,
(A) no pharmacological response occurs
(B) the drug gets metabolized
(C) neuroendocrine hormones get released
(D) DNA changes occur

27. Median lethal dose/median effective dose of a drug is called
(A) Therapeutic subsistence
(B) Therapeutic index
(C) Therapeutic window
(D) Therapeutic efficacy

28. The anti-diabetic drug recently in the news for its probable relation to bladder cancer is
(A) Nateglinide (B) Sitagliptin (C) Pioglitazone (D) Metformin

29. Inert substance given in the garb of medicine is called
(A) Placebo (B) Vaccine (C) Toxoid (D) Multivitamin

30. The structure carrying deoxygenated blood is
(A) Artery (B) Lymphatic (C) Vein (D) Nerve

31. Which of these vitamins is water soluble?
(A) A (B) D (C) E (D) C

32. Deficiency of which vitamin causes Pellagra?
(A) Riboflavin (B) Niacin (C) Biotin (D) Methylcobalamin

33. Which of these drugs is used as a diuretic?
(A) Frusemide (B) Calutamide (C) Chlorpropamide (D) Cyclophosphamide

34. Which of these is an anticancer drug ?
(A) Ticarcillin (B) Tigecycline (C) Teicoplanin (D) Carboplatin

35. Which of the following drugs is likely to be tapered and stopped?
(A) Amoxycillin (B) DEC (C) Prednisolone (D) Meropenem

36. Wilson s disease is associated with metabolism of
(A) Iron (B) Zinc (C) Aluminium (D) Copper

37. Antidote for heparin is
(A) N-acetylcysteine (B) Glucagon (C) Methylene blue (D) Protamine

38. Which of the following is used as an antiepileptic drug?
(A) Phenobarbitone (B) Penicillin (C) Varenicline (D) Acarbose

39. Which of the antihypertensive drugs has dry cough as a side effect?
(A) Ganglion blockers (B) Calcium channel blockers (C) Diuretics (D) ACE inhibitors

40. Which of these drugs is likely to be used weekly once?
(A) Amoxycillin (B) Methotrexate (C) Atorvastatin (D) Sulphasalazine

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41. Which of the following is an antifungal agent?
(A) Ciprofloxacin (B) Ornidazole (C) Miconazole (D) Albendazole

42. The normal fasting blood sugar value is around
(A) 50mg/dL (B) 100mg/dL (C) 150 mg/dL (D) 200mg/dL

43. Chemical energy at the cellular level is in the form of
(A) NADH (B) ATP (C) NADPH (D) SOD

44. Glycolysis results in conversion of glucose to
(A) Fructose (B) Glyceraldehyde (C) Pyruvate (D) Acetoacetate

45. Which material is predominantly used in the sphygmomanometer?
(A) Selenium (B) Silver (C) Mercury (D) Cyanide

46. Which of the following effects is not mediated by Histamine type 2 receptors ?
(A) Vasodilatation (B) Bronchoconstriction (C) Gastric acid secretion (D) Tachycardia

47. Which of the following drugs cannot be given as intravenous bolus shot?
(A) Potassium chloride (B) Adenosine (C) Insulin (D) Dextrose

48. Which of these drugs is most likely to be used by a cardiologist?
(A) Streptokinase (B) Anti-venom (C) Doxycycline (D) Sevelamer

49. Which of these diseases is a psychiatric disease?
(A) Schizophrenia (B) Glaucoma (C) Prolapse

50. Deficiency of what causes rickets?
(A) Vitamin A (B) Vitamin D (C) Iron (D) Copper

51. Which of these is not a HMG-CoA reductase inhibitor?
(A) Ulinastatin (B) Simvastatin (C) Pitavastatin (D) Atorvastatin

52. Normal WBC count range in the blood is
(A) 1.5 lakh to 4 lakh/cu.ml.
(B) 4000-10000/cu.ml.
(C) 4.5 million to 5.5 million /cu.ml.
(D) 100-400/cu.ml.

53. The hardest substance in the human body is
(A) Bone (B) Cartilage (C) Dentine (D) Ligament

54. The nasogastric tube used for enteral feeding is called
(A) Steven's tube (B) Sengstaken blackmore tube (C) Ryle’s tube (D) Foley's tube

55. The best treatment modality for uncomplicated non-infective diarrhea is
(A) Antibiotics (B) Loperamide (C) Ranitidine (D) ORS

56. Rods and cones are part of
(A) Inner ear (B) Liver (C) Breast (D) Eye

57. Which of the following is not used sublingually?
(A) Isosorbide dinitrate (B) Nifedepine (C) Nitrofurantoin (D) Nitroglycerine

58. Laplace’s law is followed by all except
(A) Brain (B) Heart (C) Urinary bladder (D) Stomach

59. Which of the following organs in the human body is gender-specific?
(A) Spleen (B) Prostate (C) Lingula (D) Pinna

60. Which of the following structures in the human body is not gender-specific?
(A) Seminal vesicle (B) Fimbria (C) Left atrium (D) CowpeFs gland

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61. Tympanic membrane is a part of
(A) Ear (B) Diaphragm (C) Heart (D) Appendix

62. The total volume of blood in the human body is around
(A) 1 litre (B) 3 litres (C) 5 litres (D) 7 litres

63. Which of the following anti-hypertensive drugs is not safe in pregnancy?
(A) Ramipril (B) Atenolol (C) Methyldopa (D) Hydralazine

64. Proprietary name of a drug in drug nomenclature refers to
(A) Chemical name (B) Generic name (C) Brand name (D) Scientific body name

65. All these drugs are ineffective orally due to liver metabolism except
(A) Testosterone (B) Insulin (C) Lidocaine (D) NTG

66. Bioavailability of a drug by which route reaches 100%? 
(A) Oral (B) IV (C) Nasal (D) Topical

67. Knee cap is the common name for   
(A) Patella (B) Fibula (C) Scaphoid (D) Femur

68. The RNA contains all except
(A) Thymine (B) Uracil (C) Adenine (D) Guanine

69. Goitre is a condition affecting the
(A) Lower limb (B) Scrotum (C) Thyroid (D) Nasal cavity

70. Which of these structures in the body is unpaired ?
 (A) Ureter (B) Optic nerve (C) Spleen (D) Stapedius

71. Hoffman s elimination refers to drug elimination by
(A) Gel matrix formation
(B) Aerosol evaporation
(C) Molecular reorganization
(D) Enzymatic degradation

72. Normal glomerular Alteration rate in adults is
 (A) 75 ml/min (B) 100 ml/min  (C) 200 ml/min (D) 125 ml/min

73. The functional unit of the lungs is
(A) Alveolus (B) Nephron (C) Myocyte (D) Reticulocyte

74. Serum creatinine helps in measuring the function of
 (A) Liver (B) Kidney (C) Lung (D) Muscle

75. Which of these is not a part of liver function test?
 (A) Prothrombin time (B) sGOT  (C) GGT (D) Mean corpuscular volume

76. The term ESR stands for 
(A) Extensive Sibilant Ronchi
(B) Extra-Sensory Receptors
(C) Equal Sinus Rhythm
(D) Erythrocyte Sedimentation Rate

77. VDRL test is associated with 
 (A) HIV (B) Syphilis (C) Gonorrhea (D) Hepatitis B

78. Which of the following diseases is spread through the faecal-oral route ?
 (A) Hepatitis A (B) Hepatitis B  (C) Hepatitis C (D) Hepatitis D

79. Malaria is caused by
(A) Bacteria (B) Virus (C) Parasite (D) Mosquito

80. The aperture of the human lenses is called
(A) Iris (B) Cornea (C) Retina (D) Pupil

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81. Abnormal perception in the absence of a stimulus is called
(A) Delusion (B) Illusion (C) Hallucination (D) Emotion

82. Which of these is not used parenterally ?
(A) Cefotaxim (B) Amikacin (C) Cefixime
(D) Vancomycin

83. Dubois formula is used to calculate
(A) Body surface area
(B) Body mass index
(C) Individual child dose

(D) Weight height ratio

84. Rapid development of tolerance to a drug is called
(A) Tachyphylaxis (B) Anaphylaxis (C) intolerance (D) Resistance

85. Toxic effects of a drug at usual therapeutic doses is called
(A) Intolerance (B) Secondary effect (C) Idiosyncracy (D) Hypersensitivity

86. Capacity of drug to produce foetal abnormalities is called
(A) Mutagenicity (B) Carcinogenicity (C) Teratogenicity (D) None

87. All are used in the prophylaxis of migraine except
(A) Propranolol (B) Flunarizine (C) Amitryptiline (D) Sumariptan

88. Insulin is synthesized in the cells of pancreas.
(A) Alpha (B) Beta (C) Delta (D) None

89. Which of these is a sulfonylurea?
(A) Miglitol (B) Acarbose (C) Gliclazide (D) Metformin

90. Which of the following acts by inhibition of carbonic anhydrase ?
(A) Spironolactone (B) Acetazolamide (C) Indapamide (D) Chlorthalidone

91. All are vitamin K dependant clotting factors except
(A) Factor 7 (B) Factor 9 (C) Factor 10 (D) Factor 13

92. Which of the following is not a second line anti Tubercular agent?
(A) Ethionamide (B) Cyclosporine (C) Capreomycin (D) Cycloserine

93. The anti tubercular agent associated with side effect of optic neuritis is
(A) Isoniazid (B) Rifampicin (C) Pyrazinamide (D) Ethambutol

94. Which of the following is used in treatment of Addisons disease?
(A) steroid (B) statin (C) sulfasalazine (D) sulfonylureas

95. What is the dose of Telmisartan used in hypertension ?
(A) 5 mg (B) 16 mg (C) 40 mg (D) 50 mg

96. What is the maximum daily dose of metformin ?
(A) 500 mg (B) 100 mg (C) 2000mg (D) 850 mg

97. Which of these is not a long acting insulin ?
(A) Degludec (B) Lispro (C) Glargine (D) Detemir

98. Which condition commonly causes severe pain, redness and swelling of the first metatarsal joint ?
(A) Rheumatoid arthritis (B) Gout (C) SLE (D) Osteoarthritis

99. Which of these is not an antibiotic drug ?
(A) Azithromycin (B) Linezolid (C) Cefpirome (D) Oseltamavir

100. Megaloblastic anemia occurs in deficiency of
(A) Vitamin B12 (B) Vitamin C (C) Copper (D) Vitamin A

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