SJRI Recruitment 2026 - Life Sciences / Biotechnology / Microbiology / Biochemistry / Pharmacology Apply

The St. John's Research Institute (SJRI) is a part of the St John's National Academy of Health Sciences, which is run by the CBCI Society for Medical Education. From its inception, St. John's has set before it an ideal of excellence in academic courses as well as service to society as a result of which it has truly become holistic both in its outlook and in its approach to the problems of community health.

Post : Project Research Scientist -I (Non Medical)- ICMR BLUE SHOCK Trail Project

Job Summary : Septic shock is a common and highly lethal ICU condition; Indian ICU data report mortality of up to 50–55%. A key driver of refractory vasodilation is excessive nitric oxide production through the NO–cGMP pathway. Methylene blue, an inhibitor of this pathway, is inexpensive and widely available, but high-quality evidence on its early use in septic shock — particularly from Indian ICUs — is lacking. BLUE-SHOCK is a single-centre, prospective, randomized, open-label, blinded outcome assessment (PROBE), parallel-group controlled trial. One hundred adults meeting Sepsis-3 criteria for septic shock will be randomized 1:1, within 24 hours of vasopressor initiation, to receive either adjunctive intravenous methylene blue along with standard guideline-based care, or standard care alone. The primary outcome is time to shock reversal (cessation of vasopressors for ≥ 6 consecutive hours). Secondary outcomes include cumulative norepinephrine-equivalent dose, mean arterial pressure, cardiac output and systemic vascular resistance over the first 48 hours, lactate clearance, duration of mechanical ventilation, ICU length of stay, 28-day mortality, adverse events, and ICU treatment cost. The study will also explore biomarker-based (IL-6, procalcitonin) and hemodynamic phenotypes associated with treatment response.

Salary : Rs.72,800/- p.m

No of Vacancy : One

Key Responsibilities :
Overall day-to-day scientific and operational management of the trial, including:
• Screening of ICU admissions against Sepsis-3 eligibility criteria and maintenance of the screening and enrolment log.
• Coordinating the informed consent process with the investigators, including consent from legally authorized representatives and re-consent on recovery of capacity
• Implementing randomization and allocation concealment procedures (sequentially numbered opaque sealed envelopes) and safeguarding allocation records.
• Supervising administration of the study intervention per protocol and monitoring protocol adherence and deviations.
• Coordinating advanced hemodynamic monitoring (cardiac output, SVR, stroke volume variation), serial ABG/lactate sampling and biomarker (IL-6, procalcitonin) collection, storage and assay scheduling with the laboratory.
• Supervising the work of the Project Technical Support–III staff and ensuring complete, accurate and timely CRF completion.
• Database design and management, data quality control, periodic data audits, query resolution and preparation of the final cleaned dataset.
• Coordinating statistical analysis with the study statistician and assisting in interpretation of results.
• Recording, documenting and reporting adverse events and serious adverse events to the PI and the Institutional Ethics Committee; maintaining pharmacovigilance and safety records.
• Maintaining regulatory and ethics documentation, CTRI registration and updates, SOPs and the trial master file; preparing progress, utilization and interim reports for ICMR.
• Assisting in training of investigators and ICU staff on protocol and data collection procedures.
• Assisting in preparation of manuscripts, conference presentations and the final project report.
• Any other scientific or administrative task assigned by the Principal Investigator in connection with the project.

Preferred Qualifications
Essential :
• First Class post-graduate degree, including an integrated post-graduate degree, in Life Sciences / Biotechnology / Microbiology / Biochemistry / Pharmacology / Clinical Research / Public Health or an allied discipline from a recognized university; OR
• Second Class post-graduate degree, including an integrated post-graduate degree, with a Doctorate degree (Ph.D.) in a relevant subject from a recognized university.

Desirable :
• Ph.D. or M.Phil. in a relevant subject; or a post-graduate qualification in clinical research / clinical epidemiology.
• GCP (Good Clinical Practice) and ICMR National Ethical Guidelines certification.
• Working knowledge of biostatistics and statistical software (SPSS / R / STATA) and of electronic data capture systems (REDCap or equivalent).
• Prior publications in peer-reviewed journals

Age Limit : 35 Years
Preferred Language : English

Tentative Date of Joining : 15th October 2026

To Apply : E-mail cover letter and curriculum vitae with 3 references (names and email addresses / phone numbers) by on or before 9th October 2026 to mathangi.krishnakumar@stjohns.in & cc to hr@sjri.res.in