Work as Early Stage Researcher at Genova, IIT
Istituto Italiano di Tecnologia (IIT) is a Foundation governed by Articles 14 et seq of the Italian Civil Code, established by Legislative Decree 269/03, converted by Law no. 326/2003 (Article 4 of the Statute), and financed by the State to conduct scientific research in the public interest, for the purpose of technological development.
Post : Early Stage Researcher
The Nanomaterials for Biomedical Applications research line led by Dr. Teresa Pellegrino at the Istituto Italiano di Tecnologia (IIT) Genoa, (Italy) is happy to announce the availability of 2 Early Stage Researcher (ESR) positions of EU Marie Sklodowska-Curie Actions (MSCA).
The positions are for a fixed-term of 3 years and the successful applicants are expected to register for PhD at University of Genoa,(Italy), starting November 2020.
These positions are funded by the HeatNMof H2020 project (G.A. N. 860942), an EU Innovative Training Network of MSCA aiming to develop smart multifunctional drug nanocarriers based on versatile porous biocompatible nanometric Metal Organic Frameworks, associated with exceptional drug payloads and controlled releases, and photo- and/or magnetic inorganic nanoparticles, providing both a specific control of reactions inside living entities and additional properties such as imaging and/ or hyperthermia therapy. The successful development of this project, involving academic and industrial partners, will contribute not only to improve the highly societal relevant cancer therapy but also to train the next generation of materials scientists in a highly interdisciplinary and intersectorial research environment.
Project Title : Engineering the surface of magnetic nanoparticles with metal organic framework
CB : 78369
PhD activities :
The aim of this PhD project is to produce novel nanoplatform made of combination of magnetic nanoparticles and metal organic framework (MOF) for drug delivery applications. The candidate will learn and develop new protocols for the synthesis of magnetic nanoparticles at controlled size, shape, composition and structure (e.g., core-shell) prepared by solvothermal and/or thermal decomposition approaches and develop new coating methods using either surfactants and/or polymers, to promote MOF growing while providing colloidal stability to the decorated MNPs in physiological solutions. In another approach, the PhD student will also focused on the synthesis of magnetic nanoparticles directly within the MOFs porosity and the encapsulation of drug molecules inside MOFs porosity.
The ideal candidate is a highly motivated student with MSc degree (or equivalent) in Chemistry with previous experience in organic chemistry. Additionally, experience in Inorganic synthesis of nanoparticles is not mandatory but highly appreciated. Good communication skills in English (both written and spoken) are mandatory.
Project Title ESR11 : Magnetic nanocomposites for alternating magnetic field-triggered drug release and related cellular study
CB : 78370
The aim of this PhD project is to produce magnetic and magnetic-plasmonic heterostructures properly functionalized with different drugs, characterized and study the drug release profile under alternating magnetic field with local or macroscopic heat generation. Moreover, the drug quantification release will be carried out (with or without AMF exposure) non only on the nanocomposite in test tube but also into cells. Drug effects will be followed by direct measurements by microscopy and elemental analysis but also indirectly by viability assays, fluorescent and immunistochemistry analysis. The candidate will acquire interdisciplinary skills by developing and setting new protocols to produce magnetic nanocomposites for drug delivery, and learning new characterization techniques (magnetic hyperthermia, optical and structural characterization of tumor cells, elemental analysis, immunohistochemistry etc.).
The ideal candidate is a highly motivated student with MSc degree (or equivalent) in Biology or Biotechnology with previous experience in nanoscience or nanomedicine. Additionally, experience in nanoparticles functionalization and cellular characterizations is not mandatory but highly appreciated. Good communication skills in English (both written and spoken) are mandatory.
Starting date : 01.11.2020
Applicants must satisfy the eligibility requirements for an ESR under the Horizon 2020 ITN
Programme at the date of recruitment by IIT; in particular, they should be eligible to be appointed as an ESR in Italy by satisfying the following criteria:
• to have less than 4 years research careers after Undergraduate/Masters graduation (this is cumulative research experience and does not include management/industrial or other work experience);
• to not hold a PhD degree (PhD candidates under 4 years of registration and before completion may apply);
• to not have resided or carried out their main activity (work, studies, etc.) in Italy for more than 12 months (cumulative) in the three years immediately before their recruitment (meant as the first day of the employment of the researcher for the purposes of the action (i.e. the starting date indicated in the contract)). Compulsory national service, short stays such as holidays, and time spent as part of a procedure for obtaining refugee status under the Geneva Convention are not taken into account.
Benefits and salary:
The successful candidates will receive an attractive salary in accordance with the MSCA regulations for Early Stage Researchers. The exact (net) salary will be confirmed upon appointment and is dependent on local tax regulations and on the country correction factor (to allow for the difference in cost of living in different EU Member States). The salary includes a living allowance, a mobility allowance and a family allowance (if married). The guaranteed PhD funding is for 36 months (i.e. EC funding, additional funding is possible, depending on the local Supervisor, and in accordance with the regular PhD time in the country of origin). In addition to their individual scientific projects, all fellows will benefit from further continuing education, which includes internships and secondments, a variety of training modules as well as transferable skills courses and active participation in workshops and conferences.
How to apply
To apply for this job position, please send an email to: Teresa.firstname.lastname@example.org before 10/05/2020 quoting “ CB: 78369 Application for HeatNMof –ESR5 for project of ESR5” and “CB: 78370 Application for HeatNMof –ESR11 for project of ESR11” in the subject of the e-mail; the following documents should be enclosed:
(a) your Europass CV
(b) a personal motivation letter describing in detail the reasons behind your professional choice to join our doctoral training program (400 words)
(c) copies of academic certificates and transcripts, including (if finished) a copy of your MSc thesis
(d) a brief research proposal addressing the topic of the research project (500-1000 words)
(e) Proof of language proficiency: Language certificate, university studies in the relevant language, research stay, etc.
(f) Optional: Supporting letters
Workplace : Genova, IIT
Last Date : 15/05/2020
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