Applications are invited for Clinical fellowship and Research fellowship at Tata Trusts

 

Tata Trusts is amongst India's oldest, non-sectarian philanthropic organisations. The Trusts own two-third of the stock holding of Tata Sons, the apex company of the Tata group of companies. The wealth that accrues from this asset supports an assortment of causes, institutions and individuals in a wide variety of areas. In this manner, the profits that the Tata companies earn go back many times over to the communities they operate in. These funds have been deployed towards a whole range of community development programmes across the country, for over a 100 years now.

Post : Education grants

Clinical Fellowship in Pancreatic cancer
Applications are invited from eligible candidates for the position of a Clinical Fellow in pancreatic cancer surgery. This is a fellowship sponsored by Tata Trusts in partnership with Tata Memorial Centre for surgeons committed to learn and develop further experience, not just in complex pancreatic cancer surgeries but in the multidisciplinary management of pancreatic cancer and other pancreatic tumors

Duration: Maximum one year.

Eligibility – Age less than 35 years with MCh /DNB Surgical Oncology or MCh / DNB GI surgery or MS General surgery with 3 years’ experience in HPB surgery

Fellowship Emoluments: Rs 100,000 a month for 12 months

Fellowships Goals & objectives
This is a one-year fellowship program that is available to candidates who desire additional training in advanced pancreatic surgery and clinical pancreas cancer research. The overall goal of the fellowship is to develop and mold an academic surgical oncologist with an interest in advanced pancreatic cancer surgery and address 1 or 2 clinically relevant research issues as deemed fit by the clinical team at Tata Memorial Centre.
By the completion of the program the fellow should:

1.Develop and enhance operative technique and clinical skills in the pre- and post-operative management in pancreatic surgery with a major emphasis on minimally invasive techniques and emerging technology.

2.Work in a multi-disciplinary dedicated pancreas tumor team.

3.Develop and implement clinical research projects related to the content areas of the fellowship. Manuscript preparation, poster preparation, oral presentation, and/or book chapter preparation are expected.

 

Research Fellowship in pancreatic cancer
Applications are invited from eligible candidates for the position of a Research Fellow in pancreatic cancer. This is a sponsored fellowship by Tata Trusts in partnership with Tata Memorial Centre for 2 basic research projects on hypoxia and organoids in pancreatic cancer.

Duration: maximum of two years.

Eligibility: Age less than 35 years with MCh /DNB Surgical Oncology or MCh / DNB GI surgery or MS General surgery with 3 years’ experience in HPB surgery with a proven research interest in GI / Pancreatic Cancer OR Candidates with age less than 35 years with PhD degree in any branch of Biological Sciences with laboratory experience in molecular biology, cell biology, with a minimum of 3- 4 year post-doctoral research experience and good publication record. Candidates with experience in genomics, bioinformatics and cell culture assays and their application in pancreatic/GI cancers would be preferred.

Fellowship Emoluments: Rs 150000 a month for 24 months, a research database/journal total allowance of Rs 50000 for 24 months and a travel grant totaling Rs 500,000 (which may be relaxed if considered necessary).

Study Proposals in brief-
Study 1 – Hypoxia project
Title –Role of surgery induced hypoxia in resectable periampullary and pancreatic adenocarcinoma undergoing pancreaticoduodenectomy and its correlation with changes in cell biology.

Outline of the study-
Hypoxia is a condition of low oxygen tension, caused by a combination of poor perfusion partly due to desmoplastic stroma and increased oxygen demand due to tumor growth. Intra-tumor hypoxia has emerged as a key role player in various solid tumors including pancreatic cancer and is involved in modulating genes at various steps of carcinogenesis. pO2 in human pancreatic cancer cells has been found to be significantly low as compared to normal pancreatic parenchyma. In addition to the already existing hypoxia in the tumor micro-environment, chemical and surgery induced hypoxia can induce phenotypically aggressive drug resistant cancer stem cells. This research project intends to study whether acute surgical hypoxia during pancreaticoduodenectomy, done for pancreatic and peri-ampullary adenocarcinoma, is related to generation of stemness. It will also study about genetic markers of stemness induced by acute surgical hypoxia and the gene sequence on the intraoperative biopsy specimens obtained at different time points of surgery. This is planned to be a prospective pilot study on 20 patients of pancreatic and periampullary tumors planned for pancreaticoduodenectomy. Intraoperative wedge biopsy from tumor at different time points during vessel ligation and resection will be performed. The expression of the markers of hypoxia and their protein products (HIF1α, VEGF, CAIX, E-cadherin, N-cadherin, Vimentin, twist, SOX-2, OCT-4, NANOG, CD-24, CD-44, CD-95, CD-133, CD-166, Survivin, RAGE) will be studied using RT PCR and flow cytometry.

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